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Wound healing: The role of growth factors.

机译:伤口愈合:生长因素的作用。

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摘要

Wound healing is a complex biological process that requires cellular interactions between a variety of cells, including fibroblasts, myofibroblasts, smooth muscle cells, endothelial cells, keratinocytes and immune cells. These interactions are mediated by numerous factors such as growth factors, hormones, blood components and second messengers. Several growth factors that are released at the wound site are presumed to be necessary for wound healing. These include epidermal growth factor (EGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF), keratinocyte growth factor (KGF), platelet-derived growth factor (PDGF), transforming growth factor (TGF) and vascular endothelial growth factor (VEGF). The clinical use of growth factors to stimulate the healing of wounds is currently being investigated. Several growth factors, including PDGF, FGF-2, IGF and KGF, have been used in clinical trials, and PDGF is currently approved for use in human medicine. (c) 2003 Prous Science. All rights reserved.
机译:伤口愈合是一种复杂的生物过程,需要各种细胞之间的细胞相互作用,包括成纤维细胞,肌纤维素,平滑肌细胞,内皮细胞,角质形成细胞和免疫细胞。这些相互作用是由许多因素的介导的,例如生长因子,激素,血液成分和第二信使。假定在伤口部位释放的几种生长因子是伤口愈合所必需的。这些包括表皮生长因子(EGF),成纤维细胞生长因子(FGF),胰岛素样生长因子(IGF),角质形成细胞生长因子(KGF),血小板衍生的生长因子(PDGF),转化生长因子(TGF)和血管内皮生长因子(VEGF)。目前正在研究临床使用生长因子刺激伤口愈合。在临床试验中使用了几种生长因子,包括PDGF,FGF-2,IGF和KGF,目前批准用于人类药物的PDGF。 (c)2003年律师科学。版权所有。

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