Relugolix for the treatment of uterine fibroids

Barra F.; Seca M.; Della Corte L.; Giampaolino P.; Ferrero S.

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Relugolix for the treatment of uterine fibroids

机译：Relugolix用于治疗子宫肌瘤

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Uterine leiomyomas represent the most common form of benign gynecological tumors affecting 20-40% of women during their life. Several therapeutic options are available for treating these patients. The use of medical treatment for myomas has largely grown in the last years, in particular for women who would refuse, postpone or are not candidates for surgery. In the last years, the clinical investigation of gonadotropin-releasing hormone (GnRH) antagonists (GnRH-ants) has emerged. This class of drugs exerts pure competitive antagonistic activity on the GnRH receptor at the pituitary gland, producing an immediate stop in the release of gonadotropins and sex steroids. Relugolix is an orally active nonpeptide GnRH-ant, recently licensed for marketing in Japan for the treatment of symptoms related to uterine myomas. Currently, several phase III clinical trials are ongoing to evaluate this molecule in this setting in the U.S. and Europe.

机译：子宫平滑肌瘤代表最常见的良同妇科肿瘤，在生命中影响了20-40％的女性。有几种治疗选择可用于治疗这些患者。在过去几年中，使用医疗医疗的使用在很大一年里，特别是对于拒绝，推迟或不是手术候选人的女性而种植。在过去几年中，出现了对促胆量释放激素（GNRH）拮抗剂（GNRH-Ants）的临床调查。这类药物对垂体腺体的GNRH受体施加纯粹的竞争性拮抗活动，在促进促性腺激素和性类固醇中产生立即停留。 Relugolix是一个口头活跃的非肽GNRH-Ant，最近在日本营销销售，用于治疗与子宫肌瘤有关的症状。目前，持续几期III期临床试验可在美国和欧洲的这种环境中评估该分子。

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《Drugs of today: Medicamentos de actualidad》 |2019年第8期|共10页
作者
Barra F.; Seca M.; Della Corte L.; Giampaolino P.; Ferrero S.;
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作者单位

IRCCS Osped Policlin San Martino Acad Unit Obstet &

Gynaecol Largo R Benzi 10 I-16132 Genoa;

IRCCS Osped Policlin San Martino Acad Unit Obstet &

Gynaecol Largo R Benzi 10 I-16132 Genoa;

Univ Naples Federico II Sch Med Dept Neurosci Reprod Sci &

Dent Naples Italy;

Univ Naples Federico II Sch Med Dept Publ Hlth Naples Italy;

IRCCS Osped Policlin San Martino Acad Unit Obstet &

Gynaecol Largo R Benzi 10 I-16132 Genoa;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Relugolix; TAK-385; Uterine fibroids; Gonadotropin-releasing hormone (GnRH; LHRH) receptor antagonists; Menstrual abnormalities; Gynecological disorders; Endocrine disorders;

机译：Relugolix;Tak-385;子宫肌瘤;促性腺激素释放激素（GnRH;LHRH）受体拮抗剂;月经异常;妇科疾病;内分泌疾病;

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专利

1. Relugolix GnRH (LHRH) receptor antagonist Treatment of uterine fibroids Treatment of endometriosis-related pain Treatment of prostate cancer [J] . Elsharoud A., Ali M., Al-Hendy A. Drugs of the Future . 2019,第2期

机译：Relugolix GNRH（LHRH）受体拮抗剂治疗子宫肌瘤治疗子宫内膜异位症相关疼痛治疗前列腺癌
2. Relugolix, a novel oral gonadotropin-releasing hormone antagonist, in the treatment of pain symptoms associated with uterine fibroids: a randomized, placebo-controlled, phase 3 study in Japanese women [J] . Osuga Yutaka, Enya Kazuaki, Kudou Kentarou, Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society . 2019,第5期

机译：Relugolix，一种新型口服促性腺激素 - 释放激素拮抗剂，治疗与子宫肌瘤相关的疼痛症状：日本女性的随机，安慰剂控制，第3期第3期研究
3. Relugolix Combination Therapy for Uterine Fibroids [J] . Slomski Anita JAMA: the Journal of the American Medical Association . 2021,第16期

机译：子宫肌瘤的Relugolix组合疗法
4. Fusion of Multiple-angles Intraoperative US Images and Pretreatment MR Images for USgHIFU Treatment of Uterine Fibroid: Retrospective Evaluation Based on Clinical Dataset [C] . Cong Yang, Qianwen Huang, Xiang Ji, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2020

机译：多角度术中US图像与MR预处理图像融合治疗USgHIFU治疗子宫肌瘤：基于临床数据集的回顾性评估
5. Combined Oral Contraceptive Utilization and Uterine Fibroid Incidence and Prevalence in The Study of Environment, Lifestyle, and Fibroids (SELF) [D] . Hoffman, Sarah Ruth. 2019

机译：组合口服避孕药和子宫肌瘤发生率和患有环境，生活方式和肌瘤（自我）的研究
6. Obstetrics and Gynæcology—Placental Tissue Fresh and Old—The Evolution of the Surgical Treatment of the Broad Ligament Pedicle—A New Operation for Uterine Prolapse — Some Observations on the Pathology and Treatment of Adherent Placenta—Eclampsia Treated by Repeated Enemata of Warm Water—A Sympathetic Ganglion in the Human Ovary and Its Influence on Menstruation and Ovulation—Plans for the Delivery of Occipito-Posterior Positions — The Effect of Symphysiotomy in Permanently Enlarging the Pelvis—Antipyrin-Salol in the Treatment of Uterine Hæmorrhage — Diphtheria—Treatment of Carcinoma of the Uterus Certain Forms of Ovarian Disease and Fibroids of the Uterus by Means of Thyroid Parotid and Mammary Gland Therapeutics—The Technique of the Dilatation of the Perineum in Labor—The Diagnosis of Pregnancy by Microscopical Changes in the Urine — Hæmorrhage from a Ruptured Graafian Follicle Simulating Hæmorrage from a Ruptured Extra-Uterine Pregnancy [O] . Kedernath Das 1896

机译：妇产科—新鲜的和旧的胎盘组织—阔韧带蒂的外科治疗方法的演变—子宫脱垂的新手术—对粘着性胎盘的病理学和治疗的一些观察—通过反复的温水回肠治疗子痫人体卵巢中的交感神经节及其对月经和排卵的影响-枕后位分娩计划-交阴切开术在永久性扩大盆腔中的作用-安替比林-沙洛尔治疗子宫出血-白喉-癌的治疗甲状腺腮腺和乳腺疗法治疗子宫某些形式的卵巢疾病和子宫肌瘤—会阴扩张术—通过尿液镜检诊断妊娠—出血破裂的子宫外妊娠破裂的格拉夫卵泡模拟H
7. RELUGOLIX COMBINATION THERAPY SIGNIFICANTLY REDUCED MENSTRUAL BLOOD LOSS WITH FIRST TREATMENT CYCLE IN WOMEN WITH HEAVY MENSTRUAL BLEEDING ASSOCIATED WITH UTERINE FIBROIDS: RESULTS FROM THE LIBERTY PHASE 3 PROGRAM [O] . Roberta Venturella, Ayman Al-Hendy, Andrea S. Lukes, 2020

机译：Relugolix联合治疗在患有子宫肌瘤相关的女性中患者中的第一个治疗循环显着降低了月经血失毒，其患有重繁重的月经出血：Liberty第3阶段的结果

Relugolix for the treatment of uterine fibroids

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