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首页> 外文期刊>Drugs and aging >Calcium Channel Blockers Co-prescribed with Loop Diuretics: A Potential Marker of Poor Prescribing?
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Calcium Channel Blockers Co-prescribed with Loop Diuretics: A Potential Marker of Poor Prescribing?

机译：钙通道阻滞剂与环路利尿的共同规定：差的处方潜在标记？

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摘要

Prescribing cascades are where a drug adverse reaction is wrongly attributed to the emergence of a new condition, which leads to further drug prescribing. This promotes polypharmacy, adverse drug reactions and therapeutic burden. An example of a prescribing cascade is the co-prescribing of loop diuretics to treat the peripheral oedema caused by calcium channel blocker (CCB) drugs. Although well recognised, this is still a combination of medications taken by millions of people worldwide. CCBs have no prognostic benefit in heart failure and have an absolute risk increase for oedema of around 8-18% (number needed to harm 6-13). In the treatment of hypertension, they also increase the risk of oedema and a new diagnosis of heart failure without having any major advantages over alternative drugs. The best way to manage the oedema caused by CCBs is to switch to an alternative medication. Only where this is not possible or fails to achieve therapeutic goals would the CCB-loop diuretic combination appear to be justified. In many cases, therapeutic practice could be improved by targeting people on CCB-loop diuretic combinations for medication review. This could improve quality of life and reduce polypharmacy, adverse drug reactions, therapeutic burden and financial costs for millions of people worldwide.
机译：处方瀑布是药物不良反应错误归因于新病症的出现，这导致进一步的药物处方。这促进了多酚，不良药物反应和治疗负担。处方级联的一个例子是环路利尿剂的共同规定，以治疗由钙通道阻滞剂（CCB）药物引起的外周水肿。虽然认识到，但仍然是全世界数百万人所采取的药物组合。 CCBS在心力衰竭中没有预后益处，水肿的绝对风险增加约为8-18％（危害6-13的数量）。在治疗高血压中，它们还增加了水肿的风险以及对心力衰竭的新诊断，而不会超过替代药物的任何主要优势。管理由CCBS引起的水肿的最佳方法是切换到另类药物。只有在不可能的情况下才能才能达到治疗目标，CCB环利用组合似乎是合理的。在许多情况下，可以通过针对药物回顾的CCB环利尿组合的人来改善治疗实践。这可以提高生活质量，降低全球数百万人的多药物，不利的药物反应，治疗负担和财务成本。

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  • 来源
    《Drugs and aging》 |2020年第2期|共5页
  • 作者

    Woodford Henry J.;

  • 作者单位

    Northumbria Healthcare North Shields Tyne &

    Wear England;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
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