Peripheral Blood Mitochondrial DNA Copy Number Obtained From Genome-Wide Genotype Data Is Associated With Neurocognitive Impairment in Persons With Chronic HIV Infection

Hulgan Todd; Kallianpur Asha R.; Guo Yan; Barnholtz-Sloan Jill S.; Gittleman Haley; Brown Todd T.; Ellis Ronald; Samuels David C.; Grant Igor; Letendre Scott L.; Marcotte Thomas D.; Franklin Donald Jr.; Ellis Ronald J.; Letendre Scott; Smith Davey M.; Heaton Robert K.; Atkinson J. Hampton; Dawson Matthew; Fennema-Notestine Christine; Taylor Michael J.; Theilmann Rebecca; Gamst Anthony C.; Abramson Ian; Vaida Florin; Sacktor Ned; Rogalski Vincent; Morgello Susan; Simpson David; Mintz Letty; McCutchan J. Allen; Collier Ann; Marra Christina; Storey Sher; Gelman Benjamin; Head Eleanor; Clifford David; Al-Lozi Muhammad; Teshome Mengesha

首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Peripheral Blood Mitochondrial DNA Copy Number Obtained From Genome-Wide Genotype Data Is Associated With Neurocognitive Impairment in Persons With Chronic HIV Infection

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Peripheral Blood Mitochondrial DNA Copy Number Obtained From Genome-Wide Genotype Data Is Associated With Neurocognitive Impairment in Persons With Chronic HIV Infection

机译：从基因组基因型数据获得的外周血线粒体DNA拷贝数与慢性艾滋病毒感染的人的神经认知障碍有关

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Background: Mitochondrial DNA (mtDNA) copy number varies by cell type and energy demands. Blood mtDNA copy number has been associated with neurocognitive function in persons without HIV. Low mtDNA copy number may indicate disordered mtDNA replication; high copy number may reflect a response to mitochondrial dysfunction. We hypothesized that blood mtDNA copy number estimated from genome-wide genotyping data is related to neurocognitive impairment (NCI) in persons with HIV.

机译：背景：线粒体DNA（MTDNA）拷贝数因细胞类型和能源需求而异。血液MTDNA拷贝数与没有艾滋病毒的人的神经认知函数有关。低MTDNA拷贝数可以表明紊乱的MTDNA复制; 高拷贝数可以反映对线粒体功能障碍的反应。我们假设从基因组基因分型数据估计的血液MTDNA拷贝数与艾滋病毒的人的神经认知障碍（NCI）有关。

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来源
《JAIDS: Journal of acquired immune deficiency syndromes》 |2019年第4期|共8页
作者
Hulgan Todd; Kallianpur Asha R.; Guo Yan; Barnholtz-Sloan Jill S.; Gittleman Haley; Brown Todd T.; Ellis Ronald; Samuels David C.; Grant Igor; Letendre Scott L.; Marcotte Thomas D.; Franklin Donald Jr.; Ellis Ronald J.; Letendre Scott; Smith Davey M.; Heaton Robert K.; Atkinson J. Hampton; Dawson Matthew; Fennema-Notestine Christine; Taylor Michael J.; Theilmann Rebecca; Gamst Anthony C.; Abramson Ian; Vaida Florin; Sacktor Ned; Rogalski Vincent; Morgello Susan; Simpson David; Mintz Letty; McCutchan J. Allen; Collier Ann; Marra Christina; Storey Sher; Gelman Benjamin; Head Eleanor; Clifford David; Al-Lozi Muhammad; Teshome Mengesha;
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作者单位

Vanderbilt Univ Med Ctr A2200 Med Ctr North 1161 21st Ave South Nashville TN 37232 USA;

Cleveland Clin Fdn Lerner Res Inst 9500 Euclid Ave Cleveland OH 44195 USA;

Vanderbilt Univ Sch Med Nashville TN 37212 USA;

Case Western Reserve Univ Sch Med Case Comprehens Canc Ctr Cleveland OH USA;

Case Western Reserve Univ Sch Med Case Comprehens Canc Ctr Cleveland OH USA;

Johns Hopkins Univ Sch Med Baltimore MD USA;

Univ Calif San Diego San Diego CA 92103 USA;

Vanderbilt Univ Sch Med Nashville TN 37212 USA;

Johns Hopkins Univ Baltimore MD USA;

Johns Hopkins Univ Baltimore MD USA;

Icahn Sch Med Mt Sinai New York NY 10029 USA;

Icahn Sch Med Mt Sinai New York NY 10029 USA;

Icahn Sch Med Mt Sinai New York NY 10029 USA;

Univ Calif San Diego San Diego CA 92103 USA;

Univ Washington Seattle WA 98195 USA;

Univ Washington Seattle WA 98195 USA;

Univ Washington Seattle WA 98195 USA;

Univ Texas Galveston TX USA;

Univ Texas Galveston TX USA;

Washington Univ St Louis MO 14263 USA;

Washington Univ St Louis MO 14263 USA;

Washington Univ St Louis MO 14263 USA;

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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
DNA; mitochondrial; HIV; neurocognitive disorders;

机译：DNA;线粒体;艾滋病毒;神经认知障碍;

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专利

1. Peripheral Blood Mitochondrial DNA Copy Number Obtained From Genome-Wide Genotype Data Is Associated With Neurocognitive Impairment in Persons With Chronic HIV Infection [J] . Hulgan Todd, Kallianpur Asha R., Guo Yan, JAIDS: Journal of acquired immune deficiency syndromes . 2019,第4期

机译：从基因组基因型数据获得的外周血线粒体DNA拷贝数与慢性艾滋病毒感染的人的神经认知障碍有关
2. No reliable gene expression biomarkers of current or impending neurocognitive impairment in peripheral blood monocytes of persons living with HIV [J] . Austin Quach, Steve Horvath, Natasha Nemanim, Journal of neurovirology . 2018,第3期

机译：没有可靠的基因表达生物标志物的电流或将神经认知障碍在与艾滋病毒一起生活的外周血单核细胞中
3. Mitochondrial DNA Haplogroups and Neurocognitive Impairment During HIV Infection [J] . Hulgan Todd, Samuels David C., Bush William, Clinical infectious diseases . 2015,第9期

机译：艾滋病毒感染过程中的线粒体DNA单倍群和神经认知障碍
4. Exposure to inorganic arsenic and mitochondrial DNA copy number and telomere length in peripheral blood [C] . S.S. Ameer, Y.Y. Xu, K. Engstr?m, International Congress on Arsenic in the Environment . 2016

机译：暴露于外周血中无机砷和线粒体DNA拷贝数和端粒长度
5. Effect of APOE proxy genotype on HIV-associated neurocognitive impairment. [D] . Morgan, Erin E. 2010

机译：APOE代理基因型对HIV相关神经认知障碍的影响。
6. Association Between HIV Infection and Mitochondrial DNA Copy Number in Peripheral Blood: A Population-Based Prospective Cohort Study [O] . Jing Sun, Ryan J Longchamps, Damani A Piggott, -1

机译：HIV感染与外周血线粒体DNA拷贝数之间的关联：基于人群的前瞻性队列研究
7. Peripheral Blood Mitochondrial DNA Copy Number Obtained From Genome-Wide Genotype Data Is Associated With Neurocognitive Impairment in Persons With Chronic HIV Infection [O] . Todd Hulgan, Asha R. Kallianpur, Yan Guo, 2019

机译：从基因组基因型数据获得的外周血线粒体DNA拷贝数与慢性艾滋病毒感染的人的神经认知障碍有关

Peripheral Blood Mitochondrial DNA Copy Number Obtained From Genome-Wide Genotype Data Is Associated With Neurocognitive Impairment in Persons With Chronic HIV Infection

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