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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Randomized controlled trial assessing the effect of vitamin A supplementation on maternal morbidity during pregnancy and postpartum among HIV-infected women.
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Randomized controlled trial assessing the effect of vitamin A supplementation on maternal morbidity during pregnancy and postpartum among HIV-infected women.

机译：随机对照试验评估维生素A补充对艾滋病毒感染妇女妊娠期孕产妇发病率的影响。

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OBJECTIVE: To determine whether low-cost treatment of HIV using vitamin A would be beneficial, we examined the effect of vitamin A supplementation on morbidity of HIV-1 infected women. METHODS: We conducted a randomized, double blind placebo-controlled trial at King Edward VIII Hospital, in Durban, South Africa. In total, 312 HIV-seropositive pregnant women between 28 and 32 weeks' gestation were recruited into this trial. Patients were randomized to receive placebo or 5,000 IU retinyl palmitate and 30 mg beta-carotene daily. At delivery of their children, patients received placebo or 200,000 IU retinyl palmitate. The main outcome measures were pre- and postnatal report of HIV-related symptoms. RESULTS: Vitamin A did not confer any significant beneficial effect on the report of either HIV or pregnancy-related symptoms during the pre- or postnatal period. CONCLUSION: In this study of HIV-infected pregnant women, vitamin A supplementation given in doses designed to decrease mother-to-infant transmission did not result in significant beneficial effect on reported symptoms pre- or postnatally. Further investigation with larger number of participants, tailoring supplementation for specific clinical conditions, outside the context of pregnancy, is required to help clarify the possible clinical benefits of vitamin A.
机译：目的：确定使用维生素A的艾滋病毒的低成本治疗是否有益，我们检查了维生素A补充对HIV-1感染妇女发病率的影响。方法：在南非德班，我们在德班国王七世医院进行了随机的双盲安慰剂对照试验。总共招募了312名艾滋病毒血清阳性孕妇，妊娠期妊娠期间妊娠期孕育了。患者随机接受安慰剂或5,000 IU视黄糖棕榈酸酯，每日30毫克β-胡萝卜素。在递送孩子时，患者接受安慰剂或200,000 IU视黄糖棕榈酸酯。主要结果措施是艾滋病毒相关症状的预期和产后报告。结果：维生素A未在预期或后期期间对艾滋病毒或妊娠相关症状的报告进行任何显着的有益影响。结论：在本发明的艾滋病毒感染孕妇的研究中，维生素A旨在减少婴儿传播的剂量给出的补充并未导致预先或后期报告症状的显着有益效果。需要进一步调查更多的参与者，剪裁对妊娠范围内的特定临床条件的补充，以帮助澄清维生素A的可能临床益处。

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