p16~(INK4a) as a tumor suppressor with therapeutic applicability

Joaquim Calbo; Adela Mazo

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p16~(INK4a) as a tumor suppressor with therapeutic applicability

机译：P16〜（INK4A）作为具有治疗性适用性的肿瘤抑制器

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The P16~(INK4a/ARF) locus encodes for 2 tumor suppressor genes commonly lost during transformation and acquisition of malignancy processes. The product of p16~(INK4a) gene is a CDK inhibitor that constrains cell cycle progression in response to different proliferative stresses and participates in cell-environment signaling pathways. Restitution of p16~(INK4a) function has showed potent antitumoral activity in new gene therapy approaches and should be taken into consideration for future design of rationale and specific therapeutic strategies against cancer.

机译：P16〜（INK4A / ARF）基因座在转化和收购恶性过程中通常丢失的2个肿瘤抑制基因。 P16〜（Ink4a）基因的产物是CDK抑制剂，其响应于不同增殖应力并参与细胞 - 环境信号传导途径来限制细胞周期进展。 P16〜（Ink4a）功能的归还在新的基因治疗方法中显示出有效的抗肿瘤活性，并应考虑到未来的理由设计和对癌症的具体治疗策略的设计。

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《Drugs of the Future》 |2003年第2期|共14页
作者
Joaquim Calbo; Adela Mazo;
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Department of Biochemistry and Molecular Biology. University of Barcelona C/ Marti i Franques 1 08028 Barcelona Spain;

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正文语种 eng
中图分类药学;
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1. p16~(INK4a) as a tumor suppressor with therapeutic applicability [J] . Joaquim Calbo, Adela Mazo Drugs of the Future . 2003,第2期

机译：P16〜（INK4A）作为具有治疗性适用性的肿瘤抑制器
2. The effects of transferring tumor suppressor gene p16 INK4A to p16 INK4A -deleted cancer cells* [J] . Kye Young Lee, Chul-Gyu Yoo, Sung Koo Han, The Korean Journal of Internal Medicine . 1999,第1期

机译：将抑癌基因p16 INK4A转移至已缺失p16 INK4A的癌细胞中的作用*
3. p16^sup INK4A^ and p14^sup ARF^ Tumor Suppressor Pathways Are Deregulated in Malignant Rhabdoid Tumors [J] . Sriram Venneti Paul Le Daniel Martinez Katherine W Eaton Nikhil Shyam Kelly L Jordan-Sciutto Bruce Pawel Jaclyn A Biegel Alexander R Judkins Journal of Neuropathology and Experimental Neurology . 2011,第7期

机译：p16 ^ sup INK4A ^和p14 ^ sup ARF ^在恶性横纹肌瘤中的肿瘤抑制途径被下调
4. P16^INK4adetection using an ultra-sensitive silicon nanowire field effect transistor [C] . Jia-Yang Hung, Yankuba B. Manga, Yu-Ju Chen, International Symposium on Next Generation Electronics . 2018

机译：使用超灵敏的硅纳米线场效应晶体管进行P16 ^{INK4a 检测}
5. Inactivation of the P16(INK4a) tumor suppressor in breast tumorigenesis and immortalization [D] . Brenner, Andrew Jacob 1997

机译：P16（INK4a）抑癌剂在乳腺肿瘤发生和永生化中的失活
6. Specific Allelic Loss of p16 INK4A Tumor Suppressor Gene after Weeks of Iron-Mediated Oxidative Damage during Rat Renal Carcinogenesis [O] . Makoto Hiroyasu, Munetaka Ozeki, Haruyasu Kohda, 2002

机译：在大鼠肾脏癌变过程中铁介导的氧化损伤后数周p16 INK4A肿瘤抑制基因的特异性等位基因缺失
7. Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress [O] . Kan C, Petti C, Bracken L, 2013

机译：在人类成纤维细胞永生化过程中survivin的上调与肿瘤抑制因子p16（INK4a）蛋白的抑制有关，并赋予抗氧化性

p16~(INK4a) as a tumor suppressor with therapeutic applicability

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