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首页> 外文期刊>Biotechnology Progress >The effect of rapeseed oil uptake on the production of erythromycin andtriketide lactone by Saccharopolyspora erythraea
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The effect of rapeseed oil uptake on the production of erythromycin andtriketide lactone by Saccharopolyspora erythraea

机译：菜籽油摄入量对糖多孢红霉菌产生红霉素和三酮内酯的影响

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摘要

Saccharopolyspora erythraea was grown in an oil-based process medium at two different laboratory scales. The initial concentration of rapeseed oil in the medium was shown not to affect the growth, while addition of oil significantly increased erythromycin A production. Increasing the agitation speed at the 2 L scale increased the growth of the culture and the production of erythromycin A but had little effect on the level of oil remaining in the fermentation. Maximum oil utilization of 50% (w/w) was obtained in both 2 and 7 L cultures. Gas chromatography analysis of the process medium showed that there was no accumulation of fatty acids and glycerides during the fermentations. The specific oil utilization by the recombinant strain of S. erythraea was significantly lower compared to the wild-type strain grown at the same scale and initial oil concentration; the recombinant strain also produced lower concentrations of the novel polyketide, triketide lactone.
机译：糖多孢菌在两种不同实验室规模的油基工艺培养基中生长。菜籽油在培养基中的初始浓度显示不影响生长，而添加油则显着增加了红霉素A的产量。在2 L规模上增加搅拌速度可增加培养物的生长和红霉素A的产生，但对发酵中残留油的水平影响很小。在2 L和7 L培养物中均获得50％（w / w）的最大油利用率。过程培养基的气相色谱分析表明，发酵过程中没有脂肪酸和甘油酯的积聚。与在相同规模和初始油浓度下生长的野生型菌株相比，重组红球菌的比油利用率显着降低。重组菌株还产生了较低浓度的新型聚酮化合物三酮内酯。

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