Efficacy and Toxicity of Peritumoral Delivery of Nanoconjugated Cisplatin in an In Vivo Murine Model of Head and Neck Squamous Cell Carcinoma

Stephanie M. Cohen; Nick Rockefeller; Ridhwi Mukerji; Dianne Durham; M. Laird Forrest; Shuang Cai

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Efficacy and Toxicity of Peritumoral Delivery of Nanoconjugated Cisplatin in an In Vivo Murine Model of Head and Neck Squamous Cell Carcinoma

机译：纳米谐波顺铂中腹腔模型的临床血管凝血模型的疗效和毒性

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Importance: Treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) uses a multi-disciplinary approach often limited by the toxicity and drug resistance of platinum agents.Objectives: To test whether a nanocarrier-conjugated cisplatin boosting locoregional drug delivery improves tumor efficacy while decreasing systemic toxicity over systemic cisplatin in a murine model of locally advanced HNSCC.Design: A randomized, controlled, in vivo study compared standard cisplatin with nanocarrier (hyaluronan [HA])-conjugated cisplatin (HA-cisplatin) each at 50% of the maximum tolerated doses in a murine model of locally advanced HNSCC (10 mice/arm, each injected with 1 X 106 MDA-1986 HNSCC cells, with phosphate-buffered saline and HA-only control arms). Mice were treated for 3 weeks and observed for 3 additional weeks.

机译：重要性：局部晚期头部和颈鳞状细胞癌（HNSCC）使用多学科方法，其经常受铂试剂的毒性和耐药性限制。目的：测试纳米载波缀合的顺铂是否提高型患者药物递送改善肿瘤效力在当地先进的HNSCC.Design中的小鼠模型中降低全身性顺铂的全身毒性：随机，受控，体内研究与纳米载体（透明化碱[HA]） - 共轭的顺铂（Ha-Cisplatin）相比，50％局部晚期HNSCC（10只小鼠/臂10只小鼠/臂的鼠模型中的最大耐受剂量，每个含有1×10 6 MDA-1986 HNSCC细胞，具有磷酸盐缓冲的盐水和HA-POWN控制臂）。将小鼠进行3周并观察到3周。

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《JAMA otolaryngology-- head & neck surgery》 |2013年第4期|共6页
作者
Stephanie M. Cohen; Nick Rockefeller; Ridhwi Mukerji; Dianne Durham; M. Laird Forrest; Shuang Cai;
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Departments of Surgery (Drs S. M. Cohen Mukerji and M. S. Cohen) and Otolaryngology-Head and Neck;

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正文语种 eng
中图分类耳鼻咽喉科学;
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1. Efficacy and Toxicity of Peritumoral Delivery of Nanoconjugated Cisplatin in an In Vivo Murine Model of Head and Neck Squamous Cell Carcinoma [J] . Stephanie M. Cohen, Nick Rockefeller, Ridhwi Mukerji, JAMA otolaryngology-- head & neck surgery . 2013,第4期

机译：纳米谐波顺铂中腹腔模型的临床血管凝血模型的疗效和毒性
2. The efficacy and toxicity of S-1 and cisplatin as first-line chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma [J] . KimH.S., KimH.R., KimG.M., Cancer chemotherapy and pharmacology. . 2012,第4期

机译：S-1和顺铂作为一线化疗在复发性或转移性头颈部鳞状细胞癌中的疗效和毒性
3. The efficacy and toxicity of S-1 and cisplatin as first-line chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma [J] . Han Sang Kim, Hye Ryun Kim, Gun Min Kim, Cancer Chemotherapy and Pharmacology . 2012,第4期

机译：S-1和顺铂作为一线化疗在复发或转移性头颈鳞癌中的疗效和毒性
4. Models for predicting stage in head and neck squamous cell carcinoma using proteomic data [C] . Kaddi Chanchala D., Wang May D. Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2014

机译：利用蛋白质组学数据预测头颈部鳞状细胞癌分期的模型
5. Non-invasive in vivo assessment of tumor hypoxia using functional magnetic resonance (fMR) imaging during therapy in human head and neck squamous cell carcinoma (HNSCC) xenografts: Implications for assessing therapeutic efficacy. [D] . Bhattacharya, Arup. 2005

机译：在人头颈部鳞状细胞癌（HNSCC）异种移植物治疗期间，使用功能性磁共振（fMR）成像对肿瘤缺氧进行非侵入性体内评估：评估治疗功效的意义。
6. Efficacy and Toxicity of Peritumoral Delivery of Nanoconjugated Cisplatin in an In Vivo Murine Model of Head and Neck Squamous Cell Carcinoma [O] . Dr. Stephanie M. Cohen, Mr. Nick Rockefeller, Dr. Ridhwi Mukerji, -1

机译：纳米复合顺铂在头颈部鳞状细胞癌的体内小鼠模型中的周膜递送的功效和毒性。
7. Efficacy and Toxicity of Peritumoral Delivery of Nanoconjugated Cisplatin in an In Vivo Murine Model of Head and Neck Squamous Cell Carcinoma [O] . Stephanie M. Cohen, Nick Rockefeller, Ridhwi Mukerji, 2013

机译：纳米谐波顺铂骨质递送在颈部鳞状细胞癌体内鼠模型中的疗效和毒性

Efficacy and Toxicity of Peritumoral Delivery of Nanoconjugated Cisplatin in an In Vivo Murine Model of Head and Neck Squamous Cell Carcinoma

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