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首页> 外文期刊>Journal of Analytical Toxicology >Postmortem Fluid and Tissue Concentrations of THC, 11-OH-THC and THC-COOH
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Postmortem Fluid and Tissue Concentrations of THC, 11-OH-THC and THC-COOH

机译：后液体和THC，11-OH-THC和THC-COOH的组织浓度

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摘要

Marijuana is the most commonly abused illicit drug worldwide. Marijuana is used for its euphoric and relaxing properties. However, marijuana use has been shown to result in impaired memory, cognitive skills and psychomotor function. The Federal Aviation Administration's Civil Aerospace Medical Institute conducts toxicological analysis on aviation fatalities. Due to severe trauma associated with aviation accidents, blood is not always available; therefore, the laboratory must rely on specimens other than blood for toxicological analysis in similar to 30-40% of cases. However, the postmortem distribution of cannabinoids has not been well characterized. The purpose of this research is to evaluate the distribution of Delta(9)-tetrahydrocannabinol (THC), and its metabolites, 11-hydroxy-tetrahydrocannabinol (11-OH-THC) and THC-COOH, in postmortem fluid and tissue specimens from 11 fatal aviation accident cases (2014-2015) previously found positive for cannabinoids. Specimens evaluated, when available, included: blood, urine, vitreous humor, liver, lung, kidney, spleen, muscle, brain, heart and bile. We developed and validated (following SWGTOX guidelines) a sensitive and robust method using solid-phase extraction and liquid chromatography-tandem mass spectrometry to identify and quantify THC, 11-OH-THC and THC-COOH in postmortem fluids and tissues. The method readily identified and quantified these cannabinoids in postmortem fluids and tissues below 1 ng/mL. Qualitative cannabinoid results within each case were comparable between blood and non-blood specimens. However, there was no consistent distribution of the cannabinoids between blood and any other fluids or tissues. Therefore, while quantitative interpretation of non-blood postmortem fluid and tissues samples is not prudent, a majority of the non-blood specimens tested could be suitable alternative/supplemental choices for qualitative cannabinoid detection.
机译：大麻是全世界最常见的非法药物。大麻用于其欣快和放松的特性。但是，已显示大麻使用导致内存受损，认知技能和精神函数的障碍。联邦航空管理局的民间航天医学院对航空病情进行了毒理学分析。由于与航空事故相关的严重创伤，血液并不总是可用;因此，实验室必须依赖于血液以外的标本进行毒理学分析，类似于30-40％的病例。然而，大麻素的后期分布并未得到很好的表征。本研究的目的是评估δ（9） - β-四氢甘油（THC）及其代谢物，11-羟基 - 四氢萘酚（11-OH-THC）和THC-COOH的分布，从11时到11中的组织标本致命的航空事故案例（2014-2015）以前发现大麻素阳性。评估标本，包括：血液，尿液，玻璃体幽默，肝脏，肺，肾，脾，肌肉，脑，心脏和胆汁。我们开发和验证（遵循SWGTOX指南）一种使用固相提取和液相色谱 - 串联质谱法的敏感和鲁棒方法，以鉴定和定量淘汰后液体和组织中的THC，11-OH-THC和THC-COOH。该方法在低于1ng / ml以下的后液体和组织中容易地鉴定和定量这些大麻素。在每种情况下，定性大麻素导致血液和非血液标本之间的相当。然而，血液与任何其他流体或组织之间的大麻素没有一致的分布。因此，虽然非血液后液体和组织样品的定量解释不慎重，但是测试的大部分非血样标本可能是定性大麻素检测的合适替代/补充选择。

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  • 来源
    《Journal of Analytical Toxicology》 |2017年第6期|共9页
  • 作者

    Saenz Sunday R.; Lewis Russell J.; Angier Mike K.; Wagner Jarrad R.;

  • 作者单位

    FAA Bioaeronaut Sci Res Lab Civil Aerosp Med Inst Forens Toxicol Lab AAM 610 6500 S MacArthur;

    FAA Bioaeronaut Sci Res Lab Civil Aerosp Med Inst Forens Toxicol Lab AAM 610 6500 S MacArthur;

    FAA Bioaeronaut Sci Res Lab Civil Aerosp Med Inst Forens Toxicol Lab AAM 610 6500 S MacArthur;

    Oklahoma State Univ Ctr Hlth Sci Sch Forens Sci 1111 W 17th St Tulsa OK 74107 USA;

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  • 正文语种 eng
  • 中图分类 毒物学（毒理学）;
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