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首页> 外文期刊>Journal of Analytical Toxicology >Detection of Drugs in Simultaneously Collected Samples of Oral Fluid and Blood
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Detection of Drugs in Simultaneously Collected Samples of Oral Fluid and Blood

机译：检测同时收集的口腔液和血液样本中的药物

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Simultaneously collected samples of oral fluid and blood in a naturalistic setting could provide a qualitative impression of the relative detection times of drugs in oral fluid compared to blood. The aim of this study was to compare detections of different drugs in oral fluid and blood from a large material of paired samples. The study included results from 930 paired oral fluid and blood samples collected from drivers suspected for driving under the influence of drugs. Oral fluid was collected using the Intercept device. Blood samples were screened using an ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS-MS) method and positive results were confirmed and quantified with a different analytical method. Oral fluid samples were analyzed using UHPLC-MS-MS. The drugs included in the study were: amphetamine, methamphetamine, tetrahydrocannabinol (THC), diazepam, N-desmethyldiazepam, clonazepam, alprazolam, nitrazepam, oxazepam, morphine, 6-monoacetylmorphine (6-MAM), methadone and buprenorphine. The drugs detected more frequently in oral fluid compared to blood were amphetamine (497 positive in oral fluid/408 positive in blood), methamphetamine (332/232), oxazepam (106/36), morphine (65/31) and 6-MAM (19/0). The drugs detected less frequently in oral fluid compared to blood were THC (224 positive in oral fluid/407 positive in blood), diazepam (137/160), N-desmethyldiazepam (183/188), clonazepam (148/307), alprazolam (47/68), nitrazepam (16/29) and buprenorphine (31/59). For methadone, the number of detections was the same in oral fluid and in blood (23/23). The results indicate that for amphetamine, methamphetamine, morphine and 6-MAM, relative detection time is longer in oral fluid than in blood, while for benzodiazepines, the results indicate that relative detection time is shorter in oral fluid than in blood. For oxazepam and buprenorphine, the results were dependent on the cut-off limits used. Regarding THC, the detection time in oral fluid depends on the sampling method. The relative detection time was shorter than in blood when using the Intercept device.
机译：同时收集的口腔液和血液中的血液样本可以在与血液相比，在口腔流体中的药物相对检测时间的定性印象。本研究的目的是将不同药物的检测与来自配对样品的大型材料的口腔液和血液进行比较。该研究包括930个配对的口服液和从涉嫌在药物的影响下驾驶的司机收集的血液样本。使用截距装置收集口腔流体。使用超高效液相色谱 - 串联质谱法（UHPLC-MS-MS）方法筛选血液样品，并用不同的分析方法确认并定量阳性结果。使用UHPLC-MS-MS分析口腔流体样品。该研究中包含的药物是：Amphetamine，甲基苯丙胺，四氢萘酚（THC），Diazepam，N-Desmethyldiazezam，Clonazepam，Alprazolam，Nitrazepam，Oxazep​​am，吗啡，6-单乙酰常（6-MAM），美沙酮和丁二甲酰胺。与血液相比，口服液中更频繁地检测到的药物是安非他明（在血液中的口服流体/ 408阳性阳性），甲基苯丙胺（332/232），恶唑泮（106/36），吗啡（65/31）和6姆（19/0）。与血液相比，在口腔液中检测到的药物较少（224次阳性血液中的224个阳性），Diazepam（137/160），N-Desmethyldiazepam（183/188），克隆泮（148/307），阿普唑仑（47/68），Nitrazepam（16/29）和Buprenorphine（31/59）。对于美沙酮，在口腔流体和血液中检测的数量相同（23/23）。结果表明，对于安非胺，甲基苯丙胺，吗啡和6姆，相对检测时间在口腔流体中比血液更长，而对于苯二氮卓，结果表明，相对检测时间在口腔流体中比血液更短。对于OxazePam和Buprenorphine，结果取决于所使用的截止限制。关于THC，口腔流体中的检测时间取决于采样方法。当使用拦截装置时，相对检测时间比血液短。

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