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首页> 外文期刊>Journal of applied physiology >Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin.
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Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin.

机译：编剧/运动诱导的赖氨酸乙酰化是在三胞苷中发生的另一种类型的后翻译改性。

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摘要

Titin serves important functions in skeletal muscle during exercise, and posttranslational modifications of titin participate in the regulation of titin-based sarcomeric functions. Scriptaid has exercise-like effects through the inhibition of HDAC and regulatory acetylation of proteins. However, it remains mostly unclear if exercise could result in titin's acetylation and whether Scriptaid could regulate acetylation of titin. We treated C57BL/6 mice with 6-wk treadmill exercise and 6-wk Scriptaid administration to explore Scriptaid's effects on mice exercise capacity and whether Scriptaid administration/exercise could induce titin's acetylation modification. An exercise endurance test was conducted to explore their effects on mice exercise capacity, and proteomic studies were conducted with gastrocnemius muscle tissue of mice from different groups to explore titin's acetylation modification. We found that Scriptaid and exercise did not change titin's protein expression, but they did induce acetylation modification changes of titin. In total, 333 acetylated lysine sites were identified. Exercise changed the acetylation levels of 33 lysine sites of titin, whereas Scriptaid changed acetylation levels of 31 titin lysine sites. Exercise treatment and Scriptaid administration shared 11 lysine sites. In conclusion, Scriptaid increased exercise endurance of mice by increasing the time mice spent running to fatigue. Acetylation is a common type of posttranslational modification of titin, and exercise/Scriptaid changed the acetylation levels of titin and titin-interacting proteins. Most importantly, titin may be a mediator through which Scriptaid and exercise modulate the properties and functions of exercise-induced skeletal muscle at the molecular level. NEW & NOTEWORTHY Scriptaid administration increased mouse exercise endurance. Acetylation is another type of posttranslational modification of titin. Scriptaid/exercise changed acetylation levels of titin and titin-interacting proteins. Titin may mediate exercise-induced skeletal muscle properties and functions.
机译：TITIN在运动期间在骨骼肌中供应重要功能，并且铁蛋白的后翻译改性参与了基于三肽的SARComeric功能的调节。通过抑制HDAC和蛋白质的调节乙酰化具有类似的效果。然而，它仍然尚不清楚运动是否可能导致三肽的乙酰化，并且编制手术程序是否可以调节三肽的乙酰化。我们处理了6-WK跑步机运动和6 WK Scripcor Administration的C57BL / 6只小鼠，探索Scriptaid对小鼠锻炼能力的影响，以及编制手术授权/锻炼是否可以诱导三肽的乙酰化改性。进行了一种锻炼耐久性测试以探讨它们对小鼠运动能力的影响，并用来自不同组的小鼠的胃肠肌组织进行蛋白质组学研究，以探索三肽的乙酰化改性。我们发现编剧和锻炼没有改变三肽的蛋白质表达，但它们确实诱导乙酰化修饰的三肽改性。总共鉴定了333个乙酰化赖氨酸位点。运动改变了三胞苷的33个赖氨酸位点的乙酰化水平，而Scriptaid改变了31种丙酮赖氨酸位点的乙酰化水平。行使处理和Scriptaid管理共享11个赖氨酸网站。总之，通过增加跑到疲劳的时间小鼠来增加小鼠的锻炼耐力。乙酰化是丙二醇的常见类型的翻译改性，并且运动/编目方案改变了三肽和三肽相互作用蛋白的乙酰化水平。最重要的是，三肽可以是介质，通过该调解员通过该调解员和锻炼在分子水平下调节运动诱导的骨骼肌的性质和功能。新的和值得注意的编制文档管理增加了鼠标锻炼耐力。乙酰化是另一种类型的三肽的后期改性。编目/运动改变了三肽和三肽相互作用蛋白的乙酰化水平。三肽可以介导运动诱导的骨骼肌性质和功能。

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