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首页> 外文期刊>Journal of applied toxicology >Salinity-dependent toxicity of water-dispersible, single-walled carbon nanotubes to Japanese medaka embryos
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Salinity-dependent toxicity of water-dispersible, single-walled carbon nanotubes to Japanese medaka embryos

机译：盐度依赖于水分散，单壁碳纳米管到日本Medaka胚胎的血清毒性

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摘要

To investigate the effects of salinity on the behavior and toxicity of functionalized single-walled carbon nanotubes (SWCNTs), which are chemical modified nanotube to increase dispersibility, medaka embryos were exposed to non-functionalized single-walled carbon nanotubes (N-SWCNTs), water-dispersible, cationic, plastic-polymer-coated, single-walled carbon nanotubes (W-SWCNTs), or hydrophobic polyethylene glycol-functionalized, single-walled carbon nanotubes (PEG-SWCNTs) at different salinities, from freshwater to seawater. As reference nanomaterials, we tested dispersible chitin nanofiber (CNF), chitosan-chitin nanofiber (CCNF) and chitin nanocrystal (CNC, i.e. shortened CNF). Under freshwater conditions, with exposure to 10mgl(-1)W-SWCNTs, the yolk sacks of 57.8% of embryos shrank, and the remaining embryos had a reduced heart rate, eye diameter and hatching rate. Larvae had severe defects of the spinal cord, membranous fin and tail formation. These toxic effects increased with increasing salinity. Survival rates declined with increasing salinity and reached 0.0% in seawater. In scanning electron microscope images, W-SWCNTs, CNF, CCNF and CNC were adsorbed densely over the egg chorion surface; however, because of chitin's biologically harmless properties, only W-SWCNTs had toxic effects on the medaka eggs. No toxicity was observed from N-SWCNT and PEG-SWCNT exposure. We demonstrated that water dispersibility, surface chemistry, biomedical properties and salinity were important factors in assessing the aquatic toxicity of nanomaterials. Copyright (c) 2016 John Wiley & Sons, Ltd.
机译：为了研究盐度对官能化的单壁碳纳米管（SWCNT）的行为和毒性的影响，这是化学改性的纳米管以增加分散性，Medaka胚胎暴露于非官能化的单壁碳纳米管（N-SWCNT），水分散性，阳离子，塑料 - 聚合物涂覆的单壁碳纳米管（W-SWCNT），或在不同盐水的不同盐度的单壁碳纳米管（PEG-SWCNT），从淡水到海水。作为参考纳米材料，我们测试了可分散的甲蛋白纳米纤维（CNF），壳聚糖 - 邻丁蛋白纳米纤维（CCNF）和几丁蛋白纳米晶（CNC，即缩短的CNF）。在淡水条件下，暴露于10mgL（-1）W-Swcnts，胚胎袋的蛋白质缩短，剩余的胚胎具有减少的心率，眼睛直径和孵化率。幼虫具有脊髓，膜翅片和尾部形成的严重缺陷。随着盐度的增加，这些毒性效果增加。生存率随着盐度的增加而下降，海水达到0.0％。在扫描电子显微镜图像中，W-SWCNTS，CNF，CCNF和CNC密集地吸附在鸡蛋绒毛膜表面上;然而，由于甲壳素的生物学无害的特性，只有W-SWCNTS对Medaka鸡蛋有毒作用。从N-SWCNT和PEG-SWCNT暴露中没有观察到毒性。我们证明水分散性，表面化学，生物医学性质和盐度是评估纳米材料水生毒性的重要因素。版权所有（c）2016 John Wiley＆Sons，Ltd。

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