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首页> 外文期刊>Journal of applied toxicology >Lipopolysaccharide levels adherent to PM2.5 play an important role in particulate matter induced‐immunosuppressive effects in mouse splenocytes
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Lipopolysaccharide levels adherent to PM2.5 play an important role in particulate matter induced‐immunosuppressive effects in mouse splenocytes

机译：抗粘附于PM2.5的脂多糖水平在小鼠脾细胞中颗粒物质诱导 - 免疫抑制作用中起重要作用

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摘要

Abstract Epidemiological studies show that exposure to ambient particulate matter (PM) is associated with serious adverse health effects, including, but not limited to, those on the respiratory system. In the present study, we investigated the splenic response in mice administered PM of d 2.5 ?m diameter (PM2.5). Male BALB/c mice (7 or 8 weeks old) were intratracheally administered PM2.5 (0.1爉g) four times, at 2爓eek intervals, and dissected 24爃 after the final administration. The effect of six types of PM2.5, collected in Shenyang or Beijing (China) and Kitakyushu (Japan), on splenocytes was examined. Our results revealed a strong correlation between the levels of lipopolysaccharide (LPS), but not that of ?glucan and polycyclic aromatic hydrocarbons, attached to PM2.5 and the effect of PM2.5 on cell activity. PM2.5 with a low amount of LPS (PM2.5LL) reduced splenocyte mitogeninduced proliferation and cytokine production compared with that in control mice. The suppressive effects of PM2.5LL on proliferation and interleukin2 production in splenocytes were rescued by the antioxidantN acetylcysteine. Expression of heme oxygenase1 was elevated after PM2.5LL administration, particularly in CD11b?+ 燾ells, while no elevation was observed in CD4+ , CD8+ or B220+ cells. Further, dissociation of the nuclear factor erythroid 2related factor 2 from Kelchlike ECHassociating protein 1 was observed in splenocytes of PM2.5LLadministered mice. These data suggest that LPS attached to PM2.5 modulates the splenocyte immune responses to PM2.5.
机译：摘要流行病学研究表明，暴露于环境颗粒物质（PM）与严重的不良健康影响有关，包括但不限于呼吸系统的影响。在本研究中，我们研究了D 2.5·M直径（PM2.5）的小鼠中的脾反应。雄性BALB / C小鼠（7或8周龄）在脑内施用PM2.5（0.1℉）四次，以2‰EEK间隔，并在最终管理后分解24‰。研究了六种PM2.5，沉阳或北京（中国）和Kitakyushu（日本）的效果，对脾细胞进行了研究。我们的结果揭示了脂多糖水平（LPS），但不是葡聚糖和多环芳烃的水平与PM2.5的水平与PM2.5对细胞活性的影响之间存在强烈的相关性。与对照小鼠相比，PM2.5具有少量LPS（PM2.5LL）降低的脾细胞促吐毒细胞诱导的增殖和细胞因子产生。通过抗氧化物乙酰琥珀酰氨基，PM2.5LL对脾细胞增殖和白细胞介素2产生的抑制作用探讨。在PM2.5LL施用后升高血红素氧氨酸的表达，特别是在CD11b？+αells中，同时在CD4 +，CD8 +或B220 +细胞中观察到升高。此外，在PM2.5LLAdminiered小鼠的脾细胞中观察到来自Kelchliklike Echassoication蛋白1的核因子红细胞2相关因子2的解离。这些数据表明，连接到PM2.5的LPS调节PM2.5的脾细胞免疫应答。

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  • 来源
    《Journal of applied toxicology》 |2018年第4期|共9页
  • 作者

    He Cuiying; Song Yuan; Ichinose Takamichi; He Miao; Morita Kentaro; Wang Duo; Kanazawa Tamotsu; Yoshida Yasuhiro;

  • 作者单位

    Department of Immunology and Parasitology School of MedicineUniversity of Occupational and;

    Department of Immunology and Parasitology School of MedicineUniversity of Occupational and;

    Department of Health SciencesOita University of Nursing and Health Sciences2944‐9 Notsuharu Oita;

    Department of Health SciencesOita University of Nursing and Health Sciences2944‐9 Notsuharu Oita;

    Department of Immunology and Parasitology School of MedicineUniversity of Occupational and;

    Department of Immunology and Parasitology School of MedicineUniversity of Occupational and;

    Department of Immunology and Parasitology School of MedicineUniversity of Occupational and;

    Department of Immunology and Parasitology School of MedicineUniversity of Occupational and;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 毒物学（毒理学）;
  • 关键词

    HO1; immune suppression; Keap1; LPS; Nrf2; PM2.5;

    机译：HO1;免疫抑制;KEAP1;LPS;NRF2;PM2.5;

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