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首页> 外文期刊>Journal of applied toxicology >Toxicological study of metal and metal oxide nanoparticles in zebrafish
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Toxicological study of metal and metal oxide nanoparticles in zebrafish

机译：斑马鱼金属和金属氧化物纳米粒子的毒理学研究

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Metal and metal oxide nanoparticles have been widely used in catalytic, electronic and biomedical fields. It is necessary to investigate their toxicity and potential hazards to human and aquatic ecosystems. Zebrafish (Danio rerio), as a promising animal model, has been increasingly utilized to assess the toxicity of nanoparticles. Zebrafish has numerous characteristics for toxicity evaluation, such as short life cycle and high fecundity. This review describes the advantages of using zebrafish in the toxicity assessment of metal and metal oxide nanoparticles. Then we focus on the toxic effects, particularly the acute toxicity and the chronic ones, induced by nanoparticles in zebrafish. Target organ toxicities are also mentioned, including immunotoxicity, developmental toxicity, neurotoxicity, reproductive toxicity, cardiovascular toxicity and hepatotoxicity. The toxic effects of selected metal nanoparticles, including Au, Ag, Cu, and metal oxide nanoparticles such as TiO2, Al2O3, CuO, NiO and ZnO, as well as the underlying mechanisms of nanoparticles causing these effects, are also highlighted and described in detail. Furthermore, we introduce the general factors that affect nanoparticle-induced toxicity in zebrafish. The drawbacks and advantages of using the zebrafish model in nanotoxicity studies are also argued. Finally, we suggest that the application of zebrafish to assess chronic toxicity of metal and metal oxide nanoparticles and the joint toxicity of metal and metal oxide nanoparticles and other pollutants could be hot topics in nanotoxicology.
机译：金属和金属氧化物纳米颗粒已广泛用于催化，电子和生物医学领域。有必要研究他们对人和水生生态系统的毒性和潜在的危害。作为一个有前途的动物模型，斑马鱼（Danio Rerio）越来越多地利用来评估纳米颗粒的毒性。斑马鱼具有许多毒性评估特征，如短暂的生命周期和高繁殖力。该综述描述了在金属和金属氧化物纳米粒子的毒性评估中使用斑马鱼的优点。然后我们专注于毒性毒性和慢性毒性的毒性作用，特别是由斑马鱼的纳米颗粒引起的急性毒性和慢性毒性。还提到了靶器官毒性，包括免疫毒性，发育毒性，神经毒性，生殖毒性，心血管毒性和肝毒性。也突出显示所选金属纳米颗粒，包括Au，Ag，Cu和金属氧化物纳米粒子，如TiO 2，Al 2 O 3，CuO，NiO和ZnO的纳米颗粒的底层机制，并详细描述。此外，我们介绍了影响南麦草诱导的毒性毒性的一般因素。还涉及使用斑马鱼模型的缺点和优点。最后，我们建议斑马鱼的应用评估金属和金属氧化物纳米粒子的慢性毒性以及金属和金属氧化物纳米粒子和其他污染物的关节毒性可能是纳米毒理学的热门话题。

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