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首页> 外文期刊>International journal of biomedical nanoscience and nanotechnology >Using zebrafish to study the biological impact of metal and metal oxide nanoparticles
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Using zebrafish to study the biological impact of metal and metal oxide nanoparticles

机译：使用斑马鱼研究金属和金属氧化物纳米粒子的生物影响

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摘要

The often-surprising emergent properties include toxicity. The number of new nanoparticles is growing, requiring risk evaluation. This review highlights nanotoxicology studies that use zebrafish (Danio rerio) adults and embryos as model organisms. Zebrafish have been adopted because they are well-accepted vertebrate model organisms that can be obtained in large, simultaneously developing cohorts that are transparent and easy to observe. Development of organs is extremely rapid, and acute effects on internal organ formation can be observed in living animals. Zebrafish are inexpensive to maintain. Work studying metal and metal oxide nanoparticles has shown that toxicity can be caused by the nanoparticles directly, and by dissolution of the component elements. Studies have included assessments of morphological and transcriptional changes; addressed characterisation issues, uptake and possible organ/tissue targets, mechanisms of toxicity, dissolution, aggregation, and sedimentation. More recent work has explored long term effects of exposure as life cycle studies are now being reported.
机译：通常令人惊讶的新兴特性包括毒性。新纳米粒子的数量正在增长，需要进行风险评估。这篇综述重点介绍了使用斑马鱼（成年斑马鱼）成虫和胚胎作为模型生物的纳米毒理学研究。斑马鱼之所以被采用，是因为它们是公认的脊椎动物模型生物，可以在透明的且易于观察的大型，同时发育的种群中获得。器官的发育非常迅速，并且可以在活体动物中观察到对内部器官形成的急性影响。斑马鱼维护成本低廉。对金属和金属氧化物纳米粒子的研究工作表明，毒性可能直接由纳米粒子引起，也可能由组分元素的溶解引起。研究包括对形态和转录变化的评估;解决了表征问题，摄取和可能的器官/组织靶标，毒性，溶解，聚集和沉降的机制。随着生命周期研究的报道，最近的工作已经探索了暴露的长期影响。

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