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首页> 外文期刊>Journal of assisted reproduction and genetics >Genetic variation in matrix metalloproteinase MMP2 and MMP9 as a risk factor for idiopathic recurrent spontaneous abortions in an Indian population
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Genetic variation in matrix metalloproteinase MMP2 and MMP9 as a risk factor for idiopathic recurrent spontaneous abortions in an Indian population

机译：基质金属蛋白酶MMP2和MMP9作为印度人群特发性复发自发性流产的危险因素的遗传变异

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摘要

Matrix metalloproteinases, MMP2 and MMP9, are found to have an important role during ovulation and pregnancy because of their capacity to degrade components of the extracellular matrix (ECM) thereby facilitating cell migration and angiogenesis. In this respect, the aim of the present study was to evaluate the association of the promoter polymorphisms -1306 C > T and -1562 C/T in MMP2 and MMP9 respectively with couples diagnosed with idiopathic recurrent spontaneous abortions (IRSA). The expression levels of these two genes were also studied in fetal tissue.
机译：基质金属蛋白酶，MMP2和MMP9被发现在排卵期和妊娠期间具有重要作用，因为它们使细胞外基质（ECM）的组分降低，从而促进细胞迁移和血管生成。 在这方面，本研究的目的是评估促进剂多态性-1306c> t和-1562c / t的关联分别与诊断出特发性复发自发性流动（IRSA）的夫妻。 还在胎儿组织中研究了这两个基因的表达水平。

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