SEARCHING FOR TRANSCRIPTION FACTOR BINDING SITE CLUSTERS: HOW TRUE ARE TRUE POSITIVES?

William Krivan

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SEARCHING FOR TRANSCRIPTION FACTOR BINDING SITE CLUSTERS: HOW TRUE ARE TRUE POSITIVES?

机译：搜索转录因子绑定站点集群：真正的阳性如何？

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摘要

The computational detection of functional transcription factor binding sites in genomic sequence is one of the challenges of the post-genomic era. Several groups have approached this problem from different directions and have demonstrated considerable success. The purpose of this communication, however, is to point out an imperfection in the way computational results are commonly reported that may lead to a distorted picture of the performance of existing algorithms.

机译：基因组序列中功能转录因子结合位点的计算检测是基因组时代的挑战之一。几个群体从不同方向接近这个问题，并且已经表现得相当大。然而，这种通信的目的是指出计算结果通常报告的方式的缺陷，这可能导致现有算法的性能的扭曲图像。

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来源
《Journal of Bioinformatics and Computational Biology》 |2004年第2期|共4页
作者
William Krivan;
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作者单位

ZymoGenetics Inc. 1201 Eastlake Avenue East Seattle Washington 98102 USA;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Predictive methods; transcriptional regulatory regions;

机译：预测方法;转录监管区域;

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专利

1. SEARCHING FOR TRANSCRIPTION FACTOR BINDING SITE CLUSTERS: HOW TRUE ARE TRUE POSITIVES? [J] . William Krivan Journal of Bioinformatics and Computational Biology . 2004,第2期

机译：搜索转录因子绑定站点集群：真正的阳性如何？
2. Cluster Analyzer for Transcription Sites (CATS): a C++-based program for identifying clustered transcription factor binding sites [J] . Han Yu, Andrew S. Yoo, va Greenwald Bioinformatics . 2004,第7期

机译：转录位点群集分析器（CATS）：基于C ++的程序，用于识别簇状转录因子结合位点
3. Cytoplasmic immunoreactivity of thyroid transcription factor-1 (clone 8G7G3/1) in hepatocytes: true positivity or cross-reaction? [J] . Gu K, Shah V, Ma C, American journal of clinical pathology. . 2007,第3期

机译：肝细胞中甲状腺转录因子-1（克隆8G7G3 / 1）的细胞质免疫反应：真正的阳性或交叉反应？
4. Simultaneous Identification for Synergistic Transcription Factors and their Transcription Factor Binding Sites [C] . Tsai Zing Tsung-Yeh, Huang Grace Tzu-Wei, Tsai Huai-Kuang 2011 International Conference on Complex, Intelligent and Software Intensive Systems . 2011

机译：协同转录因子及其转录因子结合位点的同时鉴定
5. Positive and negative regulation of neuroendocrine gene expression by zinc finger transcription factors: Identification of a negative retinoic acid response element in the rat oxytocin promoter, and the cloning of a novel factor binding a conserved element critical for effective expression of the growth hormone gene [D] . Lipkin, Steven Monroe 1993

机译：锌指转录因子对神经内分泌基因表达的正向和负向调节：鉴定大鼠催产素启动子中的视黄酸阴性反应元件，并克隆与保守元件结合的新型因子，该元件对于生长激素基因的有效表达至关重要
6. Author Correction: True equilibrium measurement of transcription factor-DNA binding affinities using automated polarization microscopy [O] . Christophe Jung, Peter Bandilla, Marc von Reutern, -1

机译：作者更正：使用自动偏振显微镜对转录因子-DNA结合亲和力进行真正的平衡测量
7. Cluster Analyzer for Transcription Sites (CATS): a C++-based program for identifying clustered transcription factor binding sites [O] . H. Yu, A. S. Yoo, I. Greenwald 2004

机译：用于转录站点的集群分析器（CAT）：基于C ++的基于C ++的程序，用于识别集群转录因子绑定站点

SEARCHING FOR TRANSCRIPTION FACTOR BINDING SITE CLUSTERS: HOW TRUE ARE TRUE POSITIVES?

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