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首页> 外文期刊>Journal of biochemical and molecular toxicology >Aryl hydrocarbon-estrogen alpha receptor-dependent expression of miR-206, miR-27b, and miR-133a suppress cell proliferation and migration in MCF-7 cells
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Aryl hydrocarbon-estrogen alpha receptor-dependent expression of miR-206, miR-27b, and miR-133a suppress cell proliferation and migration in MCF-7 cells

机译：MiR-206，miR-27b和miR-133a的芳基烃 - 雌激素α受体依赖性表达抑制MCF-7细胞中细胞增殖和迁移

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摘要

The underlying functions of miR-206, miR-133a, miR-27b, and miR-21, and their link to the estrogen receptor alpha (ER alpha) and aryl hydrocarbon receptor (AhR) signaling pathways remain largely unexplored. In this study, we detect the expression of miR-206, miR-133a, miR-27b, and miR-21 in MCF-7 through quantificational real-time polymerase chain reaction assay along with the activation/inhibition of ER alpha and AhR receptors. Aside from this, cell proliferation and migration as well as AhR-dependent CYP1A1 enzyme activity were measured. Here, we found that the forced increased expression of miR-206, miR-133a, and miR-27b were closely associated with the suppression of MCF-7 cell proliferation and migration. The anti-proliferative-metastatic effect of miR-206, miR-133a, and miR-27b was probably mediated by targeting the ER alpha and AhR signaling pathways. Considered together, our study indicated that the overexpression of miR-206, miR-133a, and miR-27b might be potential biomarkers for prognosis and therapeutic strategies in breast cancer.
机译：miR-206，miR-133a，miR-27b和miR-21的基础功能及其与雌激素受体α（ERα）和芳基烃受体（AHR）信号传导途径的链接仍然很大程度上是未探斗的。在该研究中，我们通过定量实时聚合酶链反应测定和ERα和AHR受体的激活/抑制检测MIR-206，MIR-133a，miR-27b和miR-21中的miR-206，miR-133a，miR-27b和miR-21的表达。除此之外，测量细胞增殖和迁移以及AHR依赖性CYP1A1酶活性。在这里，我们发现miR-206，miR-133a和miR-27b的强制增加表达与抑制MCF-7细胞增殖和迁移密切相关。 MiR-206，miR-133a和miR-27b的抗增殖 - 转移效果可能是通过靶向ERα和AHR信号传导途径介导的。我们的研究表明，MIR-206，MIR-133A和MIR-27B的过度表达可能是患有乳腺癌预后和治疗策略的潜在生物标志物。

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