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首页> 外文期刊>Journal of biochemical and molecular toxicology >Mitigative effects of epigallocatechin gallate in terms of diminishing apoptosis and oxidative stress generated by the combination of lead and amyloid peptides in human neuronal cells
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Mitigative effects of epigallocatechin gallate in terms of diminishing apoptosis and oxidative stress generated by the combination of lead and amyloid peptides in human neuronal cells

机译：EPigallocateChin Gallate在人神经元细胞中铅和淀粉样蛋白肽组合产生的凋亡和氧化应激递减和氧化应激的可缓解作用

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Abstract Environmental exposure to lead (Pb) is reported to associate with the development of Alzheimer's disease, where the formation of β‐amyloid peptides (APs) of (1‐40), (1‐42), and (25‐35) is considered as the major risk factor. In this context, we aimed at investigating the effect of epigallocatechin gallate (EGCG), a major flavonoid polyphenol available in green tea, in mitigating the individual and combined toxicity generated by Pb and β‐APs in terms of oxidative stress and apoptosis in human neuronal cells. SH‐SY5Y cells were exposed to Pb and β‐APs of (1‐40) and (25‐35) individually and in different combinations in the presence and absence of EGCG. The results indicated that EGCG mitigated both Pb‐ and β‐AP‐induced oxidative stress in scavenging reactive oxygen species and apoptosis by improving the expression levels of Bax and bcl2 and inhibiting annexin V and caspase‐3. Thus, our study shows that EGCG protects SH‐SY5Y cells against the cytotoxicity induced by Pb and β‐APs by decreasing oxidative stress and inhibiting apoptosis.
机译：据报道，摘要环境暴露于铅（PB）与阿尔茨海默病的发展缔合，其中（1-40），（1-42）和（25-35）的形成，形成β-淀粉样肽（AP）和（25-35）是被认为是主要的危险因素。在这种情况下，我们旨在研究EpigallocaTechin gallate（EGCG），绿色茶中可用的主要类黄酮多酚，在减轻Pb和β-AP产生的个体和组合毒性方面的氧化胁迫和人类神经元细胞凋亡的疗效细胞。将SH-SY5Y细胞暴露于（1-40）和（25-35）的PB和β-AP，并在存在和不存在EGCG中以不同的组合。结果表明，EGCG通过改善Bax和Bcl 2的表达水平并抑制膜蛋白V和Caspase-3，减轻了Pb和β-AP-AP诱导的氧化胁迫下的氧化胁迫和细胞凋亡。因此，我们的研究表明，EGCG通过降低氧化应激和抑制细胞凋亡来保护SH-SY5Y细胞免受PB和β-APS诱导的细胞毒性。

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