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首页> 外文期刊>Journal of biomechanical engineering. >Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts
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Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts

机译：用于组织工程血管移植的双层支架的应力分析驱动设计

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Continuing advances in the fabrication of scaffolds for tissue-engineered vascular grafts (TEVGs) are greatly expanding the scope of potential designs. Increasing recognition of the importance of local biomechanical cues for cell-mediated neotissue formation, neo-vessel growth, and subsequent remodeling is similarly influencing the design process. This study examines directly the potential effects of different combinations of key geometric and material properties of polymeric scaffolds on the initial mechanical state of an implanted graft into which cells are seeded or migrate. Toward this end, we developed a bilayered computational model that accounts for layer-specific thickness and stiffness as well as the potential to be residually stressed during fabrication or to swell during implantation. We found that, for realistic ranges of parameter values, the circumferential stress that would be presented to seeded or infiltrating cells is typically much lower than ideal, often by an order of magnitude. Indeed, accounting for layer-specific intrinsic swelling resulting from hydrophilicity or residual stresses not relieved via annealing revealed potentially large compressive stresses, which could lead to unintended cell phenotypes and associated maladaptive growth or, in extreme cases, graft failure. Metrics of global hemodynamics were also found to be inversely related to markers of a favorable local mechanobiological environment, suggesting a tradeoff in designs that seek mechanical homeostasis at a single scale. These findings highlight the importance of the initial mechanical state in tissue engineering scaffold design and the utility of computational modeling in reducing the experimental search space for future graft development and testing.
机译：在制造组织工程血管移植物（TEVG）的支架上的持续进步大大扩大了潜在设计的范围。增加对局部生物力学提示对细胞介导的新发现形成，新血管生长和随后重塑的重要性的识别在不同影响设计过程中。本研究介绍了聚合物支架关键几何和材料特性的不同组合对植入移植物的初始机械状态的不同组合的潜在影响，该植入移植物的初始机械状态或迁移到该植入物中。为此，我们开发了一种双层计算模型，其考虑了层特定的厚度和刚度以及在制造期间或在植入过程中膨胀的潜力。我们发现，对于参数值的现实范围，将呈现给播种或渗透细胞的圆周应力通常远低于理想的，通常是幅度。实际上，通过退火未释放的亲水性或残留应力产生的层特异性内在肿胀显示出潜在的大抗压应力，这可能导致意外的细胞表型和相关的不良生长，或者在极端情况下，移植物失效。还发现全球血流动力学的指标与有利的当地力学环境的标记相反，建议在单一规模上寻求机械稳态的设计中的权衡。这些发现突出了组织工程脚手架设计中初始机械状态的重要性以及计算建模在减少实验搜索空间以进行未来移植开发和测试的实用性。

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