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首页> 外文期刊>Journal of Biomechanics >Characterization and assessment of hyperelastic and elastic properties of decellularized human adipose tissues
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Characterization and assessment of hyperelastic and elastic properties of decellularized human adipose tissues

机译：脱胶人脂肪组织超痉挛性和弹性性质的特征及评价

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Decellularized adipose tissue (DAT) has shown potential as a regenerative scaffold for plastic and reconstructive surgery to augment or replace damaged or missing adipose tissue (e.g. following lumpectomy or mastectomy). The mechanical properties of soft tissue substitutes are of paramount importance in restoring the natural shape and appearance of the affected tissues, and mechanical mismatching can lead to unpredictable scar tissue formation and poor implant integration. The goal of this work was to assess the linear elastic and hyperelastic properties of decellularized human adipose tissue and compare them to those of normal breast adipose tissue. To assess the influence of the adipose depot source on the mechanical properties of the resultant decellularized scaffolds, we performed indentation tests on DAT samples sourced from adipose tissue isolated from the breast, subcutaneous abdominal region, omentum, pericardial depot and thymic remnant, and their corresponding force-displacement data were acquired. Elastic and hyperelastic parameters were estimated using inverse finite element algorithms. Subsequently, a simulation was conducted in which the estimated hyperelastic parameters were tested in a real human breast model under gravity loading in order to assess the suitability of the scaffolds for implantation. Results of these tests showed that in the human breast, the DAT would show similar deformability to that of native normal tissue. Using the measured hyperelastic parameters, we were able to assess whether DAT derived from different depots exhibited different intrinsic nonlinearities. Results showed that DAT sourced from varying regions of the body exhibited little intrinsic nonlinearity, with no statistically significant differences between the groups. (C) 2014 Elsevier Ltd. All rights reserved.
机译：脱细胞化脂肪组织（DAT）示出了作为塑料和重建手术的再生支架的潜力，以增强或替换受损或丢失的脂肪组织（例如，在肿瘤切除术或乳房切除术后）。软组织替代品的机械性能至关重要，在恢复受影响组织的自然形状和外观方面是至关重要的，并且机械错配会导致不可预测的瘢痕组织形成和植入性差的整合。这项工作的目的是评估脱细胞脂肪组织的线性弹性和超弹性性质，并将它们与正常乳腺脂肪组织的脂肪组织进行比较。为了评估脂肪贮库来源对所得脱叶支架的机械性能的影响，我们对从乳腺癌，皮下腹部区域，全膜，心包仓库和胸腺残余物中分离的脂肪组织进行的DAT样品进行压痕试验及其对应的获取力 - 位移数据。使用逆有限元算法估计弹性和超弹性参数。随后，进行了模拟，其中在重力载荷下在真正的人类乳房模型中测试了估计的高弹性参数，以评估支架的适用性植入。这些测试的结果表明，在人乳房中，DAT将显示与本地正常组织的相似可变形性。使用测量的超弹性参数，我们能够评估来自不同仓库的DAT是否表现出不同的内在非线性。结果表明，来自身体不同地区的DAT表现出少量的内在非线性，在组之间没有统计学上显着的差异。 （c）2014年elestvier有限公司保留所有权利。

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