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首页> 外文期刊>Journal of Biomechanics >Are axial intervertebral disc biomechanics determined by osmosis?
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Are axial intervertebral disc biomechanics determined by osmosis?

机译：轴向椎间盘生物力学是由渗透测定的吗？

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摘要

The intervertebral disc faces high compressive forces during daily activities. Axial compression induces creeping fluid loss and reduction in disc height. With degeneration, disc fluids and height are progressively lost, altering biomechanics. It is assumed that this reduction of fluids is caused by a decline of osmolality within the disc due to proteoglycan depletion. Here we investigate the isolated effect of a reduction in osmosis on the biomechanical properties of the intervertebral disc. Continuous diurnal loading was applied to healthy caprine intervertebral discs in a loaded disc culture system for a total of 6 days. We increased testing bath osmolality with two doses of polyethylene-glycol (PEG), thereby reducing the osmotic gradient between the disc and the surrounding fluid. This way we could study the isolated effect of reduced osmosis on axial creep, without damaging the disc. We evaluated: daily creep and recovery, recovery time-constants and compressive stiffness. Additionally, we investigated water content. There was a strong dose-dependent effect of PEG concentration on water content and axial creep behaviour: disc height, amplitude and rate of creep and recovery were all significantly reduced. Axial compressive stiffness of the disc was not affected. Reduction of water content and amplitude of creep and recovery showed similarity to degenerative disc biomechanics. However, the time-constants increased, indicating that the hydraulic permeability was reduced, in contrast to what happens with degeneration. This suggests that besides the osmotic gradient, the permeability of the tissues determines healthy intervertebral disc biomechanics. (C) 2017 Published by Elsevier Ltd.
机译：椎间盘在日常活动期间面临高压缩力。轴向压缩诱导蠕动液体损失和圆盘高度的降低。通过退化，椎间盘液和高度逐渐丢失，改变生物力学。假设由于蛋白多糖耗尽，通过盘内的渗透压率下降引起的这种流体的减少引起的。在这里，我们研究了渗透性减少对椎间盘的生物力学性质的分离效果。将持续的昼夜载荷施用于装载的盘培养系统中的健康潮碱椎间盘，共6天。我们用两种剂量的聚乙二醇（PEG）增加了测试浴Osmolality，从而减少了盘和周围流体之间的渗透梯度。这样，我们可以研究轴向蠕变减少渗透的孤立效果，而不会损坏盘。我们评估：每日蠕变和恢复，恢复时间常数和压缩刚度。此外，我们研究了含水量。 PEG浓度对水含量的强烈剂量依赖性效果，轴向蠕变行为：椎间盘高度，蠕变和恢复率均显着降低。盘的轴向压缩刚度不受影响。减少含水量和蠕变幅度和恢复的幅度与退化椎间盘生物力学相似。然而，时间常数增加，表明液压渗透率与变性发生的结果相比。这表明除了渗透梯度之外，组织的渗透率决定了健康的椎间盘生物力学。 （c）2017年由elestvier有限公司出版

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