PRESSURE-INDUCED MECHANICAL STRESS IN THE CAROTID ARTERY BIFURCATION - A POSSIBLE CORRELATION TO ATHEROSCLEROSIS

Salzar RS.; Eppink RT.; Thubrikar MJ.

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PRESSURE-INDUCED MECHANICAL STRESS IN THE CAROTID ARTERY BIFURCATION - A POSSIBLE CORRELATION TO ATHEROSCLEROSIS

机译：颈动脉分叉中的压力诱导的机械应力 - 与动脉粥样硬化的可能相关性

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A possible correlation between regions of high intramural wall stress and the development of atherosclerotic lesions in the carotid artery bifurcation is investigated. The bifurcation geometry is determined through in vivo studies, as well as the analysis of cadaver specimens. Having compiled accurate geometric data, two representative finite element models were created in order to determine the areas of localized stress concentrations that occur in the bifurcation. The artery is assumed isotropic and is mechanically loaded with an incremental pressure of 40 mmHg. A highly localized stress concentration of approximately 9 to 14 times the proximal circumferential wall stress occurs at the point of bifurcation. A lower stress concentration of approximately 3 to 4 times the proximal circumferential stress occurs over a large area of the sinus bulb. Acknowledging that these two regions of the carotid bifurcation are highly susceptible to atherosclerotic lesions, it appears possible that a correlation between wall stress and atherosclerosis may exist. [References: 30]

机译：研究了高际椎间壁应力区域之间的相关性和颈动脉分叉在颈动脉分叉中的动脉粥样硬化病变的发展。分叉几何体通过体内研究确定，以及对尸体标本的分析。已经编译了准确的几何数据，创建了两个代表性有限元模型，以便确定分叉中发生的局部应力浓度的区域。假设各向同性的动脉，并机械地装载，增量压力为40mmHg。在分叉的点处发生近端圆周壁应力的高度局部应力浓度约为9至14倍。在窦灯泡的大面积上发生近侧圆周应力的较低应力浓度约为3至4倍。承认颈动脉分叉的这两个区域高度易受动脉粥样硬化病变的影响，似乎可能存在壁应力和动脉粥样硬化之间的相关性。 [参考：30]

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来源
《Journal of Biomechanics》 |1995年第11期|共8页
作者
Salzar RS.; Eppink RT.; Thubrikar MJ.;
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作者单位

UNIV VIRGINIA DEPT CIVIL ENGN &

APPL MECH CHARLOTTESVILLE VA 22903 USA;

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原文格式 PDF
正文语种 eng
中图分类医用一般科学;生物力学;
关键词
Artery; Atherosclerosis; Wall stress; Bifurcation; Shear-stress; Elastic properties; Flow; Endothelium; Morphology; Branches; Stenosis; Aorta;

机译：动脉;动脉粥样硬化;墙应力;分叉;剪切应力;弹性性质;流动;内皮;形态;分支;狭窄;主动脉;主动脉;主动脉;主动脉;主动脉;主动脉;主动脉;主动脉;主动脉;主动脉;主动脉;主动脉;

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1. PRESSURE-INDUCED MECHANICAL STRESS IN THE CAROTID ARTERY BIFURCATION - A POSSIBLE CORRELATION TO ATHEROSCLEROSIS [J] . Salzar RS., Eppink RT., Thubrikar MJ. Journal of Biomechanics . 1995,第11期

机译：颈动脉分叉中的压力诱导的机械应力 - 与动脉粥样硬化的可能相关性
2. Correlation of coronary artery atherosclerosis with atherosclerosis of the intracranial cerebral artery and the extracranial carotid artery. [J] . Seo WK, Yong HS, Koh SB, European neurology . 2008,第6期

机译：冠状动脉粥样硬化与颅内脑动脉和颅外颈动脉的动脉粥样硬化的相关性。
3. The correlation of carotid artery calcification on panoramic radiographs and determination of carotid artery atherosclerosis with ultrasonography [J] . Lee Jae-Seo, Kim Ok-Su, Chung Hyun-Ju, Oral surgery, oral medicine, oral pathology oral radiology . 2014,第6期

机译：全景X线照片上颈动脉钙化的相关性及超声对颈动脉粥样硬化的测定
4. A Segmentation Method for Carotid Artery Atherosclerosis Plaque for MRI Contrast and MRI Features, Oxidative Stress Markers in Coronary and Carotid Plaque [C] . Rakesh Sharma, Ram B. Sigh, Raj K. Gupta IEEE Symposium on Computer-Based Medical Systems . 2003

机译：用于MRI对比度和MRI特征的颈动脉动脉粥样硬化斑块的分段方法，冠状动脉和颈动脉斑块的氧化应激标记物
5. Influence of biomechanical force and mass transfer on the progression of atherosclerosis in human carotid arteries [D] . Kim, Sungho 2011

机译：生物力学力和传质对人颈动脉粥样硬化进展的影响
6. Correlation of clinical findings duplex carotid artery scanning and CT scanning of the brain in 54 consecutive patients with bruits over the carotid artery bifurcation. [O] . R. Englund, J. Fairgrieve, P. F. Brown, 1985

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PRESSURE-INDUCED MECHANICAL STRESS IN THE CAROTID ARTERY BIFURCATION - A POSSIBLE CORRELATION TO ATHEROSCLEROSIS

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