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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Polylactic-co-glycolic acid microspheres added to fixative cements and its role on bone infected architecture
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Polylactic-co-glycolic acid microspheres added to fixative cements and its role on bone infected architecture

机译：聚乳酸共甘油酸微球加入固定水泥及其对骨感染架构的作用

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Joint prostheses are an essential element to improve quality of life. However, prostheses may fail due to several factors, including the most frequent cause, Staphylococcus aureus infection. The identification of new fixing bone cements with less reactivity on bone tissue and an adequate response to infection remains a primary challenge. The aim of this study is to evaluate the response of bone tissue in rabbits after introduction of a hydroxyapatite-coated titanium rod with a commercial fixative cement (Palacos (R)) compared to a modified experimental cement (EC) containing polylactic-co-glycolic acid (PLGA) microspheres in the presence or absence of contaminating germs. This study used 20 New Zealand rabbits which were divided into four groups (n = 5) depending on the presence or absence of S. aureus and the use of commercial (Palacos (R)) or EC. A histological method, based on bone architecture damage, was proposed to evaluate from 1 to 9 the histological results and the response of the infected tissue. The macrophage response was also evaluated using monoclonal antibody RAM-11. The study showed better bone conservation with the use of EC with PLGA microspheres against the Palacos (R) commercial cement, including the noncontaminated and contaminated groups. (c) 2019 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2517-2526, 2019.
机译：关节假体是提高生活质量的基本要素。然而，由于几个因素，假肢可能会失败，包括最常见的原因，金黄色葡萄球菌感染。骨组织对反应性较小的新固定骨水泥的鉴定以及对感染的充分反应仍然是主要挑战。该研究的目的是在与含有聚乳糖 - 共聚乙酸的改性实验水泥（EC）相比，在引入羟基磷灰石涂覆的钛棒后，评估兔骨组织患者骨组织的响应（Palaco（R））。酸（PLGA）微球在存在或不存在污染胚芽中。本研究使用了20个新西兰兔子，其分为四组（n = 5），具体取决于S.金黄色葡萄球菌的存在和不存在和使用商业（Palacos）或EC。提出了一种基于骨架构损伤的组织学方法，以评估1至9种组织学结果和感染组织的响应。还使用单克隆抗体Ram-11评估巨噬细胞反应。该研究表明，利用PLGA微球对Palacos（R）商业水泥的使用，包括eC，包括非含有和污染的群体。 （c）2019年作者。 “生物医学材料”研究第B部分：Wiley期刊出版的应用生物材料，Inc .J生物保解件B部分B：Appl Biomater 107B：2517-2526，2019。

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