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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Degradation rate of DNA scaffolds and bone regeneration
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Degradation rate of DNA scaffolds and bone regeneration

机译：DNA支架和骨再生的降解率

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Scaffolds implanted into bone defect sites must achieve optimal biodegradation rates while appropriately filling the void as new bone formation progresses. We recently developed a unique biomaterial consisting of salmon deoxyribose nucleic acid (DNA) and protamine, which can be used as an osteoconductive scaffold for tissue engineering. The aim of the present study was to elucidate how the degradation rate of the scaffold affects bone regeneration. We examined the relationships between the degradation rate of salmon DNA scaffolds and new bone formation using a rat skin flank subcutaneous model and rat calvarial defect model. The degradation rates of the scaffolds were proportional to the durations of pretreatment with ultraviolet (UV) light irradiation. The biodegradation rates of the scaffolds were also dependent on the duration of UV irradiation, as tested a subcutaneous tissue implantation. Scaffolds irradiated with UV light for 0.5 h maintained gradual biodegradation of phosphate compared with scaffolds irradiated for 0 or 3 h. In the calvarial defect model, we found that new bone formation was higher in rats treated with scaffolds irradiated with UV light for 0.5 h compared with those irradiated with UV light for 0 or 3.0 h. The present results suggest that bioengineering of scaffolds for biodegradation is important to regenerate bone. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 122-128, 2019.
机译：植入骨缺陷部位的支架必须在适当地填充空隙时达到最佳的生物降解率，因为新的骨形成进展。我们最近开发出一种独特的生物材料，其由三文鱼脱氧核酸（DNA）和protamine，其可用作组织工程的骨导电支架。本研究的目的是阐明支架的降解率如何影响骨再生。我们研究了使用大鼠皮肤侧皮模型和大鼠颅骨缺陷模型的鲑鱼DNA支架和新骨形成之间的关系与新骨形成之间的关系。支架的降解速率与用紫外（UV）光照射的预处理的持续时间成比例。支架的生物降解率也取决于UV辐射的持续时间，如测试的皮下组织注入。用UV光照射的支架保持0.5小时，而与照射0或3小时的支架相比，磷酸盐的逐渐生物降解。在颅骨缺陷模型中，我们发现用紫外线照射的支架处理的大鼠含有0.5小时的大鼠的新骨形成较高，与紫外光照射0或3.0小时。目前的结果表明，生物降解的支架的生物工程对再生骨骼很重要。 （c）2018 Wiley期刊，Inc。J生物保解员B：Appl Biomater，107B：122-128,2019。

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