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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Osteogenic apatite particles by sol–gel assisted electrospraying
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Osteogenic apatite particles by sol–gel assisted electrospraying

机译：通过溶胶 - 凝胶辅助电喷雾的骨质型磷灰石颗粒

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Abstract Electrospraying has tremendous potential to prepare submicron to nano size ceramic particles with novel properties. In this study, a sol–gel assisted electrospraying has been used to synthesise phase controlled apatite (hydroxyapatite, HA and calcium deficient hydroxyapatite, CDHA) particles. Variation in particle size was also achieved by controlling the process parameters. The particles were non cytotoxic, induced proliferation of osteoblast‐like cells (HOS) and internalised by the cells. Increased alkaline phosphatase, collagen and calcium deposition confirmed the mineralisation of cells. Expression of osteopontin, osteocalcin and alkaline phosphatase genes further ascertained that the particles promoted osteogenic commitment of the rat bone marrow‐derived mesenchymal stem cells (rBMSCs). The particles also showed better loading and release of tetracycline drug than accelerated microwave synthesised apatite particles. The methodology for synthesis of ceramic particles may have avenues for a wide range of biomedical applications. ? 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1941–1954, 2018.
机译：摘要电喷雾具有巨大的潜力，可以用新的性质制备亚微米到纳米尺寸陶瓷颗粒。在该研究中，溶胶 - 凝胶辅助电喷雾已被用于合成相控制磷灰石（羟基磷灰石，HA和缺乏羟基磷灰石，CDHA）颗粒。通过控制过程参数还实现了粒度的变化。颗粒是非细胞毒性的，诱导成骨细胞样细胞（HOS）的增殖，并由细胞内化。增加碱性磷酸酶，胶原和钙沉积证实细胞的矿化。骨桥蛋白，骨钙素和碱性磷酸酶基因的表达进一步确定了颗粒促进了大鼠骨髓衍生的间充质干细胞（RBMSCs）的骨质发生承诺。颗粒还显示出比加速微波合成磷灰石颗粒更好地装载和释放四环素药物。合成陶瓷颗粒的方法可以具有用于各种生物医学应用的途径。还2017年Wiley期刊，Inc。J生物保解员B部分B：苹果生物摩特，106B：1941-1954,2018。

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