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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effect of hydroxyapatite concentration on high‐modulus composite for biodegradable bone‐fixation devices
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Effect of hydroxyapatite concentration on high‐modulus composite for biodegradable bone‐fixation devices

机译：羟基磷灰石浓度对可生物降解骨固定装置高模量复合材料的影响

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Abstract There are over 3 million bone fractures in the United States annually; over 30% of which require internal mechanical fixation devices to aid in the healing process. The current standard material used is a metal plate that is implanted onto the bone. However, metal fixation devices have many disadvantages, namely stress shielding and metal ion leaching. This study aims to fix these problems of metal implants by making a completely biodegradable material that will have a high modulus and exhibit great toughness. To accomplish this, long‐fiber poly‐ l ‐lactic acid (PLLA) was utilized in combination with a matrix composed of polycaprolactone (PCL) and hydroxyapatite (HA) nano‐rods. Through single fibril tensile tests, it was found that the PLLA fibers have a Young's modulus of 8.09 GPa. Synthesized HA nanorods have dimensions in the nanometer range with an aspect ratio over 6. By dip coating PLLA fibers in a suspension of PCL and HA and hot pressing the resulting coated fibers, dense fiber‐reinforced samples were made having a flexural modulus up to 9.2 GPa and a flexural strength up to 187 MPa. The flexural modulus of cortical bone ranges from 7 to 25 GPa, so the modulus of the composite material falls into the range of bone. The typical flextural strength of bone is 130 MPa, and the samples here greatly exceed that with a strength of 187 MPa. After mechanical testing to failure the samples retained their shape, showing toughness with no catastrophic failure, indicating the possibility for use as a fixation material. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1963–1971, 2017.
机译：摘要在美国每年有超过300万骨骨折;超过30％需要内部机械固定装置帮助愈合过程。所用的当前标准材料是植入骨骼上的金属板。然而，金属固定装置具有许多缺点，即应力屏蔽和金属离子浸出。本研究旨在通过制造具有高模量并表现出巨大韧性的完全可生物降解的材料来解决这些金属植入物问题。为了实现这一点，长纤维多L-乳酸（PLLA）与由聚己内酯（PCL）和羟基磷灰石（HA）纳米棒组成的基质组合使用。通过单纤维拉伸试验，发现PLLA纤维具有8.09GPa的杨氏模量。合成的HA纳米棒在纳米范围内具有宽高比的宽度6.通过浸渍涂层PLLA纤维在PCL和HA的悬浮液中，并使所得涂覆的纤维的热压，使抗纤维增强样品具有高达9.2的弯曲模量GPA和弯曲强度高达187 MPa。皮质骨的弯曲模量为7-25GPa，因此复合材料的模量落入骨骼范围内。骨骼的典型粪便强度为130MPa，这里的样品大大超过了强度为187MPa。机械测试失败后，样品保留其形状，显示出韧性，没有灾难性的故障，表明用作固定材料的可能性。还2016 Wiley期刊，Inc.J生物保解员B：Appl Biomater，105B：1963-1971,2017。

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