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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Acceleration of wound healing by ultrasound activation of TiO 2 2 in Escherichia coli Escherichia coli ‐infected wounds in mice
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Acceleration of wound healing by ultrasound activation of TiO 2 2 in Escherichia coli Escherichia coli ‐infected wounds in mice

机译：在大肠杆菌大肠杆菌大肠杆菌大肠杆菌植物大肠杆菌的伤口激活加速伤口愈合

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Abstract Surgical site infections continue to be a common complication affecting surgical prognosis. Reactive oxygen species (ROS) are generated by ultrasound‐irradiated titanium dioxide (TiO 2 ) (UIT). Although excessive ROS production can cause cell damage, ROS at physiological levels mediate beneficial cellular responses, including angiogenesis. This study investigated whether UIT can promote healing of Escherichia coli‐infected wounds. We used TiO 2 and ultrasound irradiation using an ultrasonography machine at a frequency of 1.0 MHz and intensity of 0.4 W?cm ?2 . These levels are not bactericidal in vitro ; therefore, we could study the effect of UIT on E. coli survival without interference of ultrasound effects. The number of cluster of differentiation 31‐positive blood vessels, which are indicative of angiogenesis, was decreased by bacterial infection, and increased at the wound edges in the UIT‐treated infected wounds, suggesting upregulation of neovascularization by UIT. Although UIT treatment did not decrease E. coli survival in vivo , it promoted healing of the infected wounds as evidenced by a significant decrease in the wound area in the UIT‐treated mice. Our findings demonstrate that UIT promotes wound healing in surgical site infections and suggest beneficial use of the UIT‐based approach as a novel therapeutic method to treat infected surgical wounds. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2344–2351, 2017.
机译：摘要外科手术部位感染仍然是影响手术预后的常见并发症。反应性氧物质（ROS）由超声波辐照二氧化钛（TiO 2）（UIT）产生。虽然过量的ROS产量会导致细胞损伤，但在生理水平下的ROS介导有益细胞反应，包括血管生成。本研究调查了UIT是否可以促进大肠杆菌感染伤口的愈合。我们使用了使用超声机的TiO 2和超声辐射，其频率为1.0MHz，强度为0.4W≤CM≤2。这些水平在体外不是杀菌剂;因此，我们可以研究UIT对大肠杆菌存活的影响而不会干扰超声效应。通过细菌感染降低了指示血管生成的分化31正血管的数量，并在伤口边缘在UIT治疗的感染伤口中增加，表明UIT的上调新生血管。虽然UIT治疗在体内没有减少大肠杆菌存活，但它促进了感染的伤口的愈合，如UIT处理的小鼠中伤口区域的显着降低所证明。我们的研究结果表明，UIT在手术部位感染中促进伤口愈合，并建议利用基于UIT的方法作为治疗感染的手术伤口的新疗法方法。还2016 Wiley期刊，INC.J生物保解员B部分B：苹果生物摩特，105B：2344-2351,2017。

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