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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Osteogenic capacity of alkali‐free bioactive glasses. In vitro In vitro studies
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Osteogenic capacity of alkali‐free bioactive glasses. In vitro In vitro studies

机译：无碱生物活性玻璃的成骨容量。 体外研究

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Abstract The high alkali content bioactive glasses commonly used to regenerate bone in dental, orthopedic, and maxillofacial surgeries induce some cytotoxicity in surrounding tissues. The present study aims the ability of some alkali‐free bioactive glasses compositions, recently developed by our research group, to stimulate human mesenchymal stem cells (hMSCs) differentiation into osteoblasts in comparison to 45S5 Bioglass ? . The obtained results demonstrated that alkali‐free bioactive glasses possess higher stimulating towards differentiation of hMSCs in comparison to the control 45S5 Bioglass ? . The von Kossa assay demonstrated that all bioactive glasses studied were able to induce the appearance of calcium deposits even when the cells were cultured in DMEM, proving that these biomaterials per se induce hMSCs cell differentiation. It was also observed that in both cell culture medium used (DMEM, and osteogenesis differentiation medium) alkali‐free bioactive glasses clearly induced the appearance of more calcium deposits than the 45S5 Bioglass ? , indicating their greater ability to induce cell differentiation. In summary, these results indicate that alkali‐free bioactive glasses are a safe and valid alternative to 45S5 Bioglass ? . ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2360–2365, 2017.
机译：摘要常用于牙科，骨科和颌面外科手术中常用的高碱含量生物活性玻璃诱导周围组织中的一些细胞毒性。目前的研究旨在，我们的研究组最近开发的无碱性生物活性眼镜组合物的能力，以刺激人间充质干细胞（HMSCs）与45s5生物制剂相比分化为成骨细胞？ 。得到的结果表明，与对照45S5生物制剂相比，无碱生物活性玻璃对HMSC的分化具有更高的刺激Δ 。 Von Kossa测定表明，即使在DMEM中培养细胞，所研究的所有生物活性玻璃也能够诱导钙沉积物的外观，证明这些生物材料本身诱导HMSCS细胞分化。还观察到，在使用的细胞培养基中（DMEM和骨肉和成骨和成骨分化介质），无碱生物活性玻璃明显诱导比45s5的生物制品更具钙沉积物的外观？ ，表明他们更大的诱导细胞分化能力。总之，这些结果表明，无碱生物活性玻璃是45s5生物制品的安全且有效的替代品？ 。还2016 Wiley期刊，INC.J生物保解率A型B：苹果生物炉，105B：2360-2365,2017。

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