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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Fe3+/SeO42- dual doped nano hydroxyapatite: A novel material for biomedical applications
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Fe3+/SeO42- dual doped nano hydroxyapatite: A novel material for biomedical applications

机译：Fe3 + / SEO42-双掺杂纳米羟基磷灰石：一种用于生物医学应用的新型材料

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摘要

Dual ions substituted hydroxyapatite (HA) received attention from scientists and researchers in the biomedical field owing to their excellent biological properties. This paper presents a novel biomaterial, which holds potential for bone tissue applications. Herein, we have successfully incorporated ferric (Fe3+)/selenate ( SeO42-) ions into the HA structure (Ca10-x-yFey(PO4)(6-x)(SeO4)(x)(OH)(2-x-y)O-y) (Fe-SeHA) through a microwave refluxing process. The Fe-SeHA materials were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and field emission scanning electron microscopy (FESEM). XRD and FTIR analyses revealed that Fe-SeHA samples were phase pure at 900 degrees C. FESEM images showed that formation of rod-like shaped particles was inhibited dramatically with increasing Fe3+ amount. The Vickers hardness (HV) test showed that hardness values increased with increasing Fe3+ concentrations. Optical spectra of Fe-SeHA materials contained broadband over (200-600) nm. In vitro degradation and bioactivity tests were conducted in simulated body fluid (SBF). The incorporation of Fe3+/ SeO42- ions into the HA structure resulted in a remarkably higher degradation rate along with intense growth of apatite granules on the surface of the Fe-SeHA discs with Ca/P ratio of 1.35-1.47. In vitro protein adsorption assay was conducted in fetal bovine serum (FBS) and it was observed that the adsorption of serum proteins on Fe-SeHA samples significantly increased with increasing Fe3+ concentration. In vitro cytotoxicity tests were performed with human fetal osteoblast (hFOB) cell line and the results demonstrated that hFOB cells attached and proliferated faster on the Fe-SeHA materials compared to pure HA showing that Fe-SeHA materials were cytocompatible. ALP activity and intracellular calcium of hFOB cells on 1Fe-SeHA discs were statistically higher than pure HA, suggesting that presence of Fe3+ ion supported osteogenic differentiation of hFOB cells. Our results suggest that 1Fe-SeHA (0.2M Fe3+/0.5MSeO42- co-doped HA) material could be considered as a promising candidate material for orthopedic applications. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 340-352, 2018.
机译：由于其优异的生物学性质，双离子取代了羟基磷灰石（HA）的羟基磷灰石（HA）受到生物医学领域的关注。本文呈现了一种新型生物材料，其具有骨组织应用的潜力。在此，我们已经成功地将铁（Fe3 +）/硒化物（SeO 4 2-）离子（Ca 10-X-YFEY（PO4）（6-x）（SEO 4）（X）（OH）（2-XY）ON（2-XY）（2-XY42-）离子（2-xy42-）离子）（Fe-Seha）通过微波回流过程。 Fe-Seha材料的特征在于X射线衍射（XRD），傅里叶变换红外（FTIR）光谱和场发射扫描电子显微镜（FESEM）。 XRD和FTIR分析显示，Fe-Seha样品在900摄氏度下纯度纯度。FeSEM图像显示，随着Fe3 +量的增加，显着抑制了棒状成形颗粒的形成。维氏硬度（HV）测试表明，随着Fe3 +浓度的增加而增加硬度值。 Fe-Seha材料的光谱包含宽带（200-600）Nm。在模拟体液（SBF）中进行体外降解和生物活性试验。将Fe3 + / SeO 4 2的掺入HA结构中，导致具有显着较高的降解速率以及Fe-Seha圆盘表面的磷灰石颗粒的强烈生长，Ca / P比率为1.35-1.47。体外蛋白质吸附测定在胎儿牛血清（FBS）中进行，并且观察到血清蛋白在Fe-Seha样品上的吸附随着Fe3 +浓度的增加而显着增加。在体外细胞毒性试验用人胎儿成骨细胞（HFOB）细胞系进行，结果表明，与纯HA相比，在Fe-Seha材料上附着和增殖的HfoB细胞呈现出Fe-Seha材料是细胞偶体的。在1Fe-Seha圆盘上的AlP活性和细胞内钙的HFOB细胞统计学上高于纯HA，表明Fe3 +离子的存在支持的HFOB细胞的成骨分化。我们的研究结果表明，1FE-SEHA（0.2M FE3 + / 0.5mSo42-共掺杂的HA）材料可以被认为是用于整形外科应用的有希望的候选材料。 （c）2017年Wiley期刊，Inc。J生物保解率A型B：苹果生物摩特，106B：340-352，2018。

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