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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >The performance of CPC/PLGA and Bio-Oss((R)) for bone regeneration in healthy and osteoporotic rats
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The performance of CPC/PLGA and Bio-Oss((R)) for bone regeneration in healthy and osteoporotic rats

机译：CPC / PLGA和BIO-OSS（（R））在健康和骨质疏松大鼠骨再生的性能

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The current study aimed to evaluate the biological performance of calcium phosphate cement (CPC) with polylactic-co-glycolic acid (PLGA) micro-particles and Bio-Oss((R)) in ovariectomized and healthy rats. Thirty-two Wistar rats received alternating experimental CPC/PLGA and Bio-Oss((R)) in femoral condyle defects in both femurs 6 weeks after ovariectomy (OVX, n=16) or sham operation (SHAM, n=16). Six weeks after OVX or SHAM surgery, bone morphology was analyzed by in vivo computed tomography (CT) to confirm osteoporotic bone condition. Analysis of bone formation and material remnants at 4 and 12 weeks after material implantation was performed by micro-CT, descriptive histology, histomorphometry and bone dynamics by fluorochrome labeling. The in vivo CT scans showed effective induction of osteoporotic bone condition by ovariectomy. Our data showed CPC/PLGA degraded relatively faster and more steadily. However, Bio-Oss((R)) had significantly less material remnants and showed significantly more bone formation compared to CPC/PLGA. Overall, our data showed relatively high amounts of CPC/PLGA for each time point, hampering new bone formation within the defect area. Osteoporotic conditions proved to significantly affect degradation rates, but did not significantly influence bone formation. An osteoporotic bone condition affects degradation of CPC/PLGA, which is vital information for its potential use in osteoporotic conditions. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 131-142, 2018.
机译：目前的研究旨在评估磷酸钙水泥（CPC）与卵巢切除和健康大鼠中磷酸钙水泥（PLGA）微粒和生物OSS（（R））的生物学性能。在卵巢切除术（OVX，N = 16）或假操作（假，n = 16）后，32只Wistar大鼠在股骨头6周内接收到股骨髁悬浮缺陷中的交替实验CPC / PLGA和生物OSS（（R））。 OVX或假手术后六周，体内计算断层扫描（CT）分析骨形态以确认骨质疏松骨骼状况。通过通过荧光染料标记通过微型CT，描述性组织学，组织形态学和骨动力学进行材料植入后4和12周的骨形成和材料残余物分析。体内CT扫描显示卵巢切除术的有效诱导骨质疏松骨骼病症。我们的数据显示CPC / PLGA相对较快，更稳定地降低。然而，与CPC / PLGA相比，Bio-OSS（（r））具有显着较少的材料残余物，并且显示出显着更大的骨形成。总体而言，我们的数据显示每个时间点相对大量的CPC / PLGA，阻碍了缺陷区域内的新骨骼形成。骨质疏松条件证明是显着影响降解率，但没有显着影响骨形成。骨质疏松骨骼状况影响CPC / PLGA的降解，这是其在骨质疏松障碍潜在使用的重要信息。 （c）2016 Wiley期刊，Inc。J生物保解员B部分：Appl Biomater，106B：131-142,2018。

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