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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Preparation of chitosan/amino multiwalled carbon nanotubes nanocomposite beads for bilirubin adsorption in hemoperfusion
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Preparation of chitosan/amino multiwalled carbon nanotubes nanocomposite beads for bilirubin adsorption in hemoperfusion

机译：壳聚糖/氨基多壁碳纳米管的制备用于血液灌注中胆红素吸附的胆红素复合珠

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Chitosan-carbon nanotube composite beads combines the advantages of chitosan in forming a stable biocompatible framework and carbon nanotube that provide nanometer effects (high strength and high specific surface area etc.). In this study, chitosan/amino multiwalled carbon nanotubes (CS/AMWCNT) composite beads was prepared by phase-inversion method, in which CS and AMWCNT was crosslinked by ethylene glycol diglycidyl ether (EGDE). The CS/AMWCNT nanocomposite beads produced has been characterized by BET, SEM, TGA, and Raman spectroscopy which exhibited enhanced thermal stability due to the incorporation of AMWCNT. Mechanical test results showed that mechanical strength of the CS/AMWCNT composite beads was significantly enhanced when comparing to unmodified chitosan beads, the breakage percentage decreased from 34.1% to 0.67%. The adsorption capacity for bilirubin was measured in PBS and BSA solutions, and the CS/AMWCNT composite beads with 5 wt% AMWCNT showed much higher adsorption capacity (12.7 mg/g in PBS and 7.6 mg/g in BSA) to bilirubin than chitosan beads (8.5 mg/g in PBS and 4.2 mg/g in BSA). Our nanocomposite beads with excellent hemocompatibility has a high potential application in blood purification as an efficient adsorbent for bilirubin. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 96-103, 2018.
机译：壳聚糖 - 碳纳米管复合珠子结合了壳聚糖在形成稳定的生物相容性骨架和碳纳米管中的优点，可提供纳米效应（高强度和高比表面积等）。在该研究中，通过相转化方法制备壳聚糖/氨基多壁碳纳米管（CS / AMWCNT）复合珠粒，其中Cs和AmwNT通过乙二醇二缩水甘油醚（EGDE）交联。所生产的CS / AMWCNT纳米复合材料珠粒通过BET，SEM，TGA和拉曼光谱，其表现出由于AMWCNT的掺入而具有增强的热稳定性。机械测试结果表明，与未修饰的壳聚糖珠子相比，CS / AMWNT复合珠粒的机械强度显着提高，断裂率降低了34.1％至0.67％。在PBS和BSA溶液中测量胆红素的吸附能力，具有5wt％AMWCNT的Cs / Amwnt复合珠粒在比壳聚糖珠比胆红素中显示出更高的吸附容量（PBS中的12.7mg / g和7.6mg / g） （在BSA中的8.5mg / g和4.2mg / g中的4.2mg / g）。我们具有优异的血液化的纳米复合珠粒具有高潜在的血液纯化应用，作为胆红素的有效吸附剂。 （c）2016 Wiley期刊，Inc.J生物保解率A型B：Appl Biomater，106B：96-103,2018。

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