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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Ultrahigh molecular weight polyethylene/graphene oxide nanocomposites: Wear characterization and biological response to wear particles
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Ultrahigh molecular weight polyethylene/graphene oxide nanocomposites: Wear characterization and biological response to wear particles

机译：超高分子量聚乙烯/石墨烯氧化物纳米复合材料：磨损表征和磨损颗粒的生物反应

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摘要

In the field of total joint replacements, polymer nanocomposites are being investigated as alternatives to ultrahigh molecular weight polyethylene (UHMWPE) for acetabular cup bearings. The objective of this study was to investigate the wear performance and biocompatibility of UHMWPE/graphene oxide (GO) nanocomposites. This study revealed that low concentrations of GO nanoparticles (0.5 wt %) do not significantly alter the wear performance of UHMWPE. In contrast, the addition of higher concentrations (2 wt %) led to a significant reduction in wear. In terms of biocompatibility, UHMWPE/GO wear particles did not show any adverse effects on L929 fibroblast and PBMNC viability at any of the concentrations tested over time. Moreover, the addition of GO to a UHMWPE matrix did not significantly affect the inflammatory response to wear particles. Further work is required to optimize the manufacturing processes to improve the mechanical properties of the nanocomposites and additional biocompatibility testing should be performed to understand the potential clinical application of these materials. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 183-190, 2018.
机译：在总关节置换的领域中，正在研究聚合物纳米复合材料作为髋臼杯轴承的超高分子量聚乙烯（UHMWPE）的替代品。本研究的目的是研究UHMWPE /石墨烯氧化物（GO）纳米复合材料的磨损性能和生物相容性。该研究表明，低浓度的去纳米颗粒（0.5wt％）不会显着改变UHMWPE的磨损性能。相反，添加更高浓度（2wt％）导致磨损的显着减少。就生物相容性而言，UHMWPE / GO磨损颗粒没有显示出在随时间测试的任何浓度下对L929成纤维细胞和PBMNC活力的任何不利影响。此外，添加到UHMWPE基质的添加没有显着影响磨损颗粒的炎症反应。需要进一步的工作来优化制造过程以改善纳米复合材料的机械性能，并且应进行附加的生物相容性测试以了解这些材料的潜在临床应用。 （c）2016年Wiley期刊，Inc。J生物保解员B部分B：苹果生物摩特，106B：183-190,2018。

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