• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Bioactive tricalcium silicate/alginate composite bone cements with enhanced physicochemical properties
【24h】

Bioactive tricalcium silicate/alginate composite bone cements with enhanced physicochemical properties

机译：具有增强的物理化学性质的生物活性三钙/藻酸盐复合骨水泥

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previous studies have shown that tricalcium silicate bone cements possess good bioactivity and appropriate degradation rate. However, they also showed some weaknesses such as poor washout resistance, formability and injectability, which have seriously hindered their clinical applications. The purpose of this study was to develop a new type of bone cementstricalcium silicate/sodium alginate (C3S/SA) composites by utilizing the interaction of Ca ions with SA molecules, in which an interpenetrating double-network of calcium hydrate silicate (CSH) and alginate hydrogel was formed to enhance the washout resistance, formability, injectability and compressive strength of C3S. The results confirmed that the washout resistance, formability and injectability of C3S could indeed be greatly enhanced by the introduction of SA. In addition, the compressive strength of the C3S/SA composite cement with an optimum composition could reach 54 MPa, which was significantly higher than that of C3S (i.e., 35.3 MPa). Moreover, the C3S/SA composite cements retained the bioactivity of C3S, such as the activity to induce apatite formation in simulated body fluid and to promote cell proliferation. All these results indicate that the C3S/SA composite cements hold great promise as a new type of bone repair materials for further in vitro and in vivo studies. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 237-244, 2018.
机译：以前的研究表明，硅酸钙骨水泥具有良好的生物活性和适当的降解速率。然而，他们还表明了一些弱点，如耐受抗性，可重新注射性差，这严重阻碍了它们的临床应用。本研究的目的是通过利用Ca离子与SA分子的相互作用来开发一种新型的骨杂质硅酸钙/藻酸钠（C3S / SA）复合材料，其中钙水合物硅酸钙（CSH）和形成藻酸盐水凝胶以增强C3s的休抗性，可成形性，可注射性和抗压强度。结果证实，通过引入SA可以大大提高C3s的耐冲压，可成形性和可注射性。另外，具有最佳组合物的C3S / SA复合水泥的抗压强度可以达到54MPa，其显着高于C3s（即35.3MPa）。此外，C3S / SA复合水泥保留C3s的生物活性，例如在模拟体液中诱导磷灰石形成的活性，并促进细胞增殖。所有这些结果表明，C3S / SA复合水泥作为进一步的体外和体内研究的新型骨修复材料具有巨大的承诺。 （c）2017年Wiley期刊，Inc。J生物保解率A件B：苹果生物检索物，106B：237-244,2018。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号