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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In vitro In vitro analysis of biopolymer coating with glycidoxypropyltrimethoxysilane on hernia meshes
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In vitro In vitro analysis of biopolymer coating with glycidoxypropyltrimethoxysilane on hernia meshes

机译：在疝气网上用丙啶氧基丙基三甲氧基硅烷的生物聚合物涂层体外分析

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Abstract Certain coatings may improve the biocompatibility of hernia meshes. The coating with self‐assembled monolayers, such as glycidoxypropyltrimethoxysilane (GOPS) can also improve the materials characteristics of implants. This approach was not yet explored in hernia meshes. It was the aim of this work to clarify if and how hernia meshes with their three‐dimensional structure can be coated with GOPS and with which technique this coating can be best characterized. Commercially available meshes made from polypropylene (PP), polyester (PE), and expanded polytetrafluorethylene (ePTFE) have been coated with GOPS. The coatings were analyzed via X‐ray photoelectron spectroscopy (XPS), confocal laser scanning microscopy (CLSM), and cell proliferation test (mouse fibroblasts). Cell viability and cytotoxicity were tested by MTT test. With the GOPS surface modification, the adherence of mouse fibroblasts on polyester meshes and the proliferation on ePTFE meshes were increased compared to noncoated meshes. Both XPS and CLSM are limited in their applicability and validity due to the three‐dimensional mesh structure while CLSM was overall more suitable. In the MTT test, no negative effects of the GOPS coating on the cells were detected after 24?h. The present results show that GOPS coating of hernia meshes is feasible and effective. GOPS coating can be achieved in a fast and cost‐efficient way. Further investigations are necessary with respect to coating quality and adverse effects before such a coating may be used in the clinical routine. In conclusion, GOPS is a promising material that warrants further research as coating of medical implants. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1083–1090, 2017.
机译：摘要某些涂层可以改善疝气网的生物相容性。具有自组装单层的涂层，例如缩水甘油氧基丙基三甲氧基硅烷（GOP）也可以改善植入物的材料特征。疝气网眼尚未探讨这种方法。这是这项工作的目的是澄清疝气网眼的疝气与其三维结构的网格如何涂有GOPS，并且这种涂层可以最好地表征该技术。由聚丙烯（PP），聚酯（PE）和膨胀的聚四氟乙烯（EPTFE）制成的市售网格已涂覆有GOP。通过X射线光电子体光谱（XPS），共聚焦激光扫描显微镜（CLSM）和细胞增殖试验（小鼠成纤维细胞）分析涂层。通过MTT试验测试细胞活力和细胞毒性。通过GOPS表面改性，与非涂层网格相比，增加了小鼠成纤维细胞对聚酯网的粘附和EPTFE网眼的增殖。由于三维网状结构，XPS和CLSM都受到适用性和有效性的限制，而CLSM更合适。在MTT试验中，在24μm后检测到电池上的GOPS涂层对细胞的负面影响。目前的结果表明，疝气网的GOP涂层是可行的，有效的。 GOPS涂层可以以快速且经济高效的方式实现。在临床常规中可以使用涂层质量和不良反应，因此需要进一步研究。总之，GOP是一个有希望的材料，可根据医疗植入物的涂层进行进一步的研究。还2016 Wiley期刊，Inc .J生物保解率A型B：苹果生物检索物，105B：1083-1090,2017。

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