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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Development and characterization of a xenograft material from N N ew Z Z ealand sourced bovine cancellous bone
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Development and characterization of a xenograft material from N N ew Z Z ealand sourced bovine cancellous bone

机译：来自N N EW Z Z Z Z Z Z Z Z Z Z Z Z，牛肉松牛骨的开发与表征

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Abstract A xenograft (bovine hydroxyapatite [BHA]) was developed from New Zealand sourced bovine cancellous bone by a successful defatting and deproteinizing procedure. The BHA was chemically, compositionally and structurally characterized. Fourier transform infrared spectroscopy confirmed the removal of organic matter from the bone matrix and the presence of carbonate ( CO 3 2 ? ), hydroxyl (OH ? ), and phosphate ( PO 4 3 ? ) functional groups. X‐ray diffraction analysis suggested that the processed bone corresponds characteristically to hydroxyapatite (HA). SEM analysis showed that the BHA has an interconnected porous architecture with a pore diameter ranging from 100 to 700 μm while μCT analysis calculated the total porosity as 73.46%?±?1.08. Furthermore, the BHA was stable up to 1000°C and lost only 1.8% of its weight. The Ca/P molar ratio of the BHA was 1.58, which is comparable with commercially available natural HA‐Endobon ? . After 28 days of incubation in simulated body fluid (SBF), the pH value only fluctuated between 7.1 and 7.5 and the BHA scaffold did not degrade significantly by weight indicating the scaffold had excellent chemical and structural stability. In vitro studies showed the BHA was cytocompatible and supported the proliferative growth of Saos‐2 osteoblast cells. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1054–1062, 2017.
机译：摘要通过成功的脱离和脱蛋白程序从新西兰生物牛松散骨开发了一种异种移植物（牛羟基磷灰石[BHA]）。 BHA在化学上，组成和结构表征。傅里叶变换红外光谱证实从骨基质中除去有机物质和碳酸酯（CO 3 2→），羟基（OH·α）和磷酸盐（PO 4 3→）官能团。 X射线衍射分析表明，加工骨对应于羟基磷灰石（HA）。 SEM分析表明，BHA具有孔径的孔径，孔径为100至700μm，而μCT分析计算总孔隙率为73.46％？±1.08。此外，BHA稳定高达1000℃，仅损失其重量的1.8％。 BHA的Ca / P摩尔比为1.58，与商业上可获得的天然HA-Endobon相当？ 。在模拟体液（SBF）中孵育28天后，pH值仅在7.1和7.5之间波动，并且BHA支架的重量显着降低，表明支架具有优异的化学和结构稳定性。体外研究表明，BHA是细胞锁定的并且支持SAOS-2成骨细胞细胞的增殖生长。还2016 Wiley期刊，INC.J生物保解率B部分：苹果生物摩特，105B：1054-1062，2017。

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