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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Efficient penetration of ceric ammonium nitrate oxidant‐stabilized gamma‐maghemite nanoparticles through the oval and round windows into the rat inner ear as demonstrated by MRI
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Efficient penetration of ceric ammonium nitrate oxidant‐stabilized gamma‐maghemite nanoparticles through the oval and round windows into the rat inner ear as demonstrated by MRI

机译：通过椭圆形和圆形窗口将硝酸铵氧化氧化剂稳定的γ-magemite纳米粒子的高效渗透到大鼠内耳中，如MRI所证明的

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Abstract We aimed to evaluate the magnetic resonance imaging (MRI) contrast effect and delivery efficiency through the middle ear into the inner ear using novel super‐paramagnetic maghemite (γ‐Fe 2 O 3 ) nanoparticles (NPs) generated using ceric ammonium nitrate (CAN)‐mediated oxidation of Fe 3 O 4 NPs (CAN–γ‐Fe 2 O 3 NPs). The CAN–γ‐Fe2O3 NPs, having hydrodynamic diameters of 50–60 nm and potentials of +55.2 mV, displayed super‐paramagnetic behavior characterized by a saturation magnetization Ms of 75.2 emu/g NPs. The r1 and r2* relaxivity (curve slopes) values were 0.0015 and 189 mmol ?1 ?s ?1 , respectively, indicating strong T2* relaxation maghemite‐based NPs. The CAN‐γ‐Fe 2 O 3 NPs were stable in the 7.0 T magnetic field. At 3 h after the tympanic medial wall administration, the NPs had significantly located to the cochlea and vestibule. The signal started to recover at 6 h in the ipsilateral cochlea and by 2 d in the vestibule post‐administration. There was no difference in the signal intensity between the left and right ears on the 14th d. Prussian blue staining for iron demonstrated NP distribution in the inner ear tissue. The novel CAN–γ‐Fe 2 O 3 NPs are a strong MRI T2 contrast agent and penetrated the round and oval windows and have potential application in the molecular imaging of the inner ear. ? 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1883–1891, 2017.
机译：摘要我们旨在使用使用铈铵硝酸铵产生的新型超顺磁性磁石（γ-Fe 2 O 3）纳米颗粒（NPS）来评估磁共振成像（MRI）对比效果和通过中耳进入内耳）介导的Fe 3 O 4 NPS的氧化（CAN-γ-Fe 2 O 3 NPS）。 CAN-γ-FE2O3 NPS，具有50-60nm的流体动力直径和+ 55.2mV的电位，显示了通过75.2 emu / g NPS的饱和磁化强度MS为特征的超顺磁性行为。 R1和R2 *松弛率（曲线斜率）值分别为0.0015和189mmol？1？1，表示强T2 *弛豫基于Maghemite的NPS。 CAN-γ-Fe 2 O 3 NPS在7.0 T磁场中稳定。在鼓室内侧壁管理后3小时，NPS显着定位于耳蜗和前庭。信号开始在施用后，在前卫耳蜗6小时内恢复2d。第14天的左耳与右耳之间的信号强度没有差异。铁的普鲁士蓝色染色在内耳组织中显示了NP分布。新型CAN-γ-FE 2 O 3 NPS是强烈的MRI T2造影剂，并穿过圆形和椭圆形窗口，并在内耳的分子成像中具有潜在的应用。还2016年Wiley期刊，Inc。J生物保罗B：Appl Biomater，105B：1883-1891,2017。

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