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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In vivo study of self-assembled alkylsilane coated degradable magnesium devices
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In vivo study of self-assembled alkylsilane coated degradable magnesium devices

机译：自组装烷基硅烷涂覆可降解镁器件的体内研究

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Magnesium (Mg) and its alloys are candidate materials for resorbable implantable devices, such as orthopedic devices or cardiovascular stents. Mg has a number advantages, including mechanical properties, light weight, its osteogenic effects and the fact that its degradation products are nontoxic and naturally present in the body. However, production of H-2 gas during the corrosion reaction can cause formation of gas pockets at the implantation site, posing a barrier to clinical applications of Mg. It is therefore desirable to develop methods to control corrosion rate and gas pocket formation around the implants. Here we evaluate the potential of self-assembled multilayer alkylsilane (AS) coatings to control Mg device corrosion and formation of gas pockets in vivo and to assess effects of the AS coatings on the surrounding tissues in a subcutaneous mouse model over a 6 weeks' period. The coating significantly slowed down corrosion and gas pocket formation as evidenced by smaller gas pockets around the AS coated implants (ANOVA; p = 0.013) and decrease in the weight loss values (t test; p = 0.07). Importantly, the microCT and profilometry analyses demonstrated that the coating inhibited the pitting corrosion. Specifically, the roughness of the coated samples was similar to 30% lower than uncoated specimen (p = 0.02). Histological assessment of the tissues under the implant revealed no inflammation or foreign body reaction. Overall, our results demonstrate the feasibility of use of the seld assembled AS coatings for reduction of gas pocket formation around the resorbable Mg devices. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 342-351, 2019.
机译：镁（Mg）及其合金是可再吸收可植入装置的候选材料，例如整形外科器件或心血管支架。 Mg具有数量优势，包括机械性能，重量轻，其成骨效果以及其降解产物的恶毒性无毒并且天然存在于体内。然而，在腐蚀反应期间的H-2气体的生产可导致植入部位的气囊形成，使MG的临床应用构成屏障。因此，希望开发用于控制植入物周围的腐蚀速率和气体袋的方法。在这里，我们评估自组装的多层烷基硅烷（AS）涂层的潜力，以控制Mg器件腐蚀和体内气体袋的形成，并评估在6周内的皮下小鼠模型中作为涂层在周围组织上的效果。涂层显着减慢了腐蚀和气体袋的形成，如涂层植入物周围的较小气囊（ANOVA; P = 0.013）所证明，减少重量损失值（T试验; P = 0.07）。重要的是，微观和轮廓测量分析证明涂层抑制了蚀腐蚀。具体地，涂覆样品的粗糙度与未涂覆的样品低30％（P = 0.02）。植入物下组织的组织学评估显示没有炎症或异物反应。总的来说，我们的结果表明，使用SELD组装为涂层的使用可行性，用于减少可再吸收的MG器件周围的气体袋。 （c）2018 Wiley期刊，Inc.J生物保解率A型B：苹果生物摩特，107B：342-351,2019。

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