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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Apatite formation on silica gel in simulated body fluid: its dependence on structures of silica gels prepared in different media.
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Apatite formation on silica gel in simulated body fluid: its dependence on structures of silica gels prepared in different media.

机译：模拟体液中硅胶上的磷灰石形成：其对不同培养基中制备的硅胶结构的依赖性。

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摘要

It has been shown that the prerequisite for glasses and glass-ceramics to bond to living bone is the formation of a layer of biologically active bonelike apatite on their surfaces. The hydrated silica formed on the surfaces of glasses and glass-ceramics plays an important role in nucleating the apatite. In the present study, the structure of the hydrated silica responsible for the apatite nucleation was investigated in an accellular simulated body fluid with ion concentrations nearly equal to those of human blood plasma. Three kinds of porous silica gels were prepared by hydrolysis and polycondensation of tetraethoxysilane in pure water or in aqueous solution containing polyethylene glycol or polyacrylic acid. The silica gels prepared in aqueous solution containing polyethylene glycol or polyacrylic acid had micron-size interconnected pores, whereas the gel prepared in pure water did not. All the gels contained a large volume of nanometer-size pores, almost the same amounts of silanol groups and D2 defect, and showed a high dissolution rate of the silica. Despite this, only the gel prepared in the solution containing polyethylene glycol formed the apatite on its surface in the simulated body fluid. This indicates that only a certain type of structural unit of the silanol group is responsible for the apatite nucleation.
机译：已经表明，玻璃和玻璃陶瓷的先决条件与生物骨骼结合的是在它们的表面上形成一层生物活性炭磷灰石。在玻璃和玻璃陶瓷表面上形成的水合二氧化硅在嗜磷酸盐中起着重要作用。在本研究中，研究负责磷灰石成核的水合二氧化硅的结构在小型模拟体液中，离子浓度几乎等于人血浆的离子浓度。通过在纯水中的四乙氧基硅烷或含有聚乙二醇或聚丙烯酸水溶液中的四乙氧基硅烷的水解和缩聚来制备三种多孔硅胶。在含有聚乙二醇或聚丙烯酸水溶液中制备的硅胶具有微米尺寸的相互连接的孔，而在纯水中制备的凝胶没有。所有凝胶含有大量的纳米尺寸孔，几乎相同量的硅烷醇基团和D2缺陷，并显示了二氧化硅的高溶解速率。尽管如此，只有在含有聚乙二醇的溶液中制备的凝胶在模拟体液中形成了磷灰石。这表明只有硅烷醇组的某种类型的结构单元负责磷灰石成核。

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