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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Preparation of chitosan scaffolds with a hierarchical porous structure
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Preparation of chitosan scaffolds with a hierarchical porous structure

机译：用等级多孔结构制备壳聚糖支架

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Development of porous scaffolds with open surface pore structures is required for tissue engineering to deliver cells into the three‐dimensional spaces in the scaffolds and improve cell distribution. This study demonstrated a new type of funnel‐like chitosan sponge prepared using ice particulates as a template. The funnel‐like chitosan sponges had a hierarchical bilayer porous structure of a surface layer and an interconnected bulk porous layer. The top surface porous layer consisted mainly of large open pores. The bulk porous layer was beneath the large surface pores and consisted of small pores that were connected with the large surface pores. The large surface pores were dependent on the shape, dimension, and density of the embossing ice particulates, while the bulk pores were dependent on the freezing temperature. The large open surface pores and interconnected bulk pores in the funnel‐like chitosan sponges facilitated cell seeding and cell distribution from the surface into the inner bulk pores. Cells cultured in the funnel‐like chitosan sponges showed high viability, high proliferation, and homogenous tissue formation. Such funnel‐like chitosan sponges will be useful for tissue engineering. ? 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010
机译：组织工程需要开发具有开放表面孔结构的多孔支架，以将细胞输送到支架中的三维空间中，并改善细胞分布。本研究表明，使用冰颗粒作为模板制备的一种新型的漏斗状壳聚糖海绵。漏斗状壳聚糖海绵具有表面层的分层双层多孔结构和互连的块状多孔层。顶表面多孔层主要包括大开孔。块状多孔层位于大表面孔下方，由与大表面孔连接的小孔组成。大表面孔依赖于压花冰颗粒的形状，尺寸和密度，而散装孔依赖于冷冻温度。漏斗状壳聚糖海绵中的大开阔表面孔和互连的散装孔促进了从表面进入内部散装孔的细胞播种和细胞分布。在漏斗状壳聚糖海绵中培养的细胞显示出高可活力，高增殖和均匀的组织形成。这种漏斗状壳聚糖海绵将可用于组织工程。还2010 Wiley期刊，Inc。J生物密制Res P部分B：苹果生物摩特，2010

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