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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Mechanical behavior of bovine pericardium treated with hyaluronic acid derivative for bioprosthetic aortic valves
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Mechanical behavior of bovine pericardium treated with hyaluronic acid derivative for bioprosthetic aortic valves

机译：用透明质酸衍生物对生物酸性主动脉瓣治疗牛心包的力学行为

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We studied the mechanical behavior of bovine pericardium (BP) after anticalcification treatment using hyaluronic acid (HA) derivative. To simulate the physiological environment and stimulate the calcification process, the BP samples were immersed into simulated body fluid solution. We conducted scanning electron microscopy with energy dispersive X-ray spectrometry, and uniaxial mechanical tests of HA-treated and non-treated samples. Although our microstructural analyses indicated that the HA treatment actually prevents the formation of calcium phosphate deposits, the mechanical tests show significant increase of stiffness of the HA-treated samples. Using data from our mechanical tests as input parameters, we performed finite element (FE) computer simulations to estimate how this increase in the BP stiffness affects the stress distribution in the bioprosthetic leaflet. Although the maximum stress observed during the closing phase of the membrane in vivo is below the experimental yield stress in all cases we analyzed, our FE results indicate that increase of BP stiffness due to HA anticalcification treatment results in higher risk of disruption and failure of the leaflets in bioprosthetic heart valves. Since our FE results indicate that the commissure and the fixed edge are the regions that withstand the highest mechanical stresses during the closing phase, new designs of the valve might be efficient to enhance the endurance of the prosthesis. (c) 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2273-2280, 2019.
机译：使用透明质酸（HA）衍生物在静电处理后牛心包（BP）的力学行为研究。为了模拟生理环境并刺激钙化过程，将BP样品浸入模拟体液溶液中。我们用能量分散X射线光谱法进行扫描电子显微镜，以及HA处理和未处理的样品的单轴机械测试。虽然我们的微观结构分析表明，HA治疗实际上防止磷酸钙沉积物的形成，机械试验显示出HA处理样品的刚度显着增加。使用来自我们的机械测试的数据作为输入参数，我们执行了有限元（FE）计算机模拟以估计BP刚度的增加如何影响生物假体宣传叶中的应力分布。尽管在体内膜的闭合阶段观察到的最大应力低于我们分析的所有病例的实验屈服应激，但我们的FE结果表明由于HA抗诊断处理引起的BP刚度的增加导致了更高的破坏性和失败的风险生物假体心脏瓣膜的传单。由于我们的FE结果表明，联盟和固定边缘是在关闭阶段期间承受最高机械应力的区域，因此阀门的新设计可能有效地增强假体的耐久性。 （c）2019 Wiley期刊，Inc。J生物保解员B部分B：苹果生物粉末107B：2273-2280,2019。

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