...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Tsc1 Tsc1 Regulates the Balance Between Osteoblast and Adipocyte Differentiation Through Autophagy/Notch1/β‐Catenin Cascade
【24h】

Tsc1 Tsc1 Regulates the Balance Between Osteoblast and Adipocyte Differentiation Through Autophagy/Notch1/β‐Catenin Cascade

机译：TSC1 TSC1通过自噬/ Notch1 /β-catenin级联调节骨灌注细胞和脂肪细胞分化之间的平衡

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

ABSTRACT A reduction in trabecular bone mass is often associated with an increase in marrow fat in osteoporotic bones. The molecular mechanisms underlying this inverse correlation are incompletely understood. Here, we report that mice lacking tuberous sclerosis 1 ( Tsc1 ) in Osterix‐expressing cells had a significant decrease in trabecular bone mass characterized by decreased osteoblastogenesis, increased osteoclastogenesis, and increased bone marrow adiposity in vivo. In vitro study showed that Tsc1 ‐deficient bone marrow stromal cells (BMSCs) had decreased proliferation, decreased osteogenic differentiation, and increased adipogenic differentiation in association with the downregulation of Wnt/β‐catenin signaling. Mechanistically, TSC1 deficiency led to autophagy suppression and consequent Notch1 protein increase, which mediated the GSK3β‐independent β‐catenin degradation. Together, our results indicate that Tsc1 controls the balance between osteoblast and adipocyte differentiation of BMSCs. ? 2018 American Society for Bone and Mineral Research.
机译：摘要小梁骨质量的减少通常与骨质疏松骨骼中骨髓脂肪的增加有关。依据该逆相关的分子机制不完全理解。在这里，我们认为缺乏Ostorix的细胞中患有结核硬化剂1（TSC1）的小鼠的小梁骨质的显着降低，其特征在于骨纤维发生，骨细胞发生增加，骨质细胞发生增加和体内骨髓脂肪复位增加。体外研究表明，TSC1骨髓基质细胞（BMSCs）的增殖降低，成骨分化降低，以及与Wnt /β-catenin信号传导的下调相关的脂肪切分化。机械地，TSC1缺乏导致自噬抑制和随后的Notch1蛋白质增加，介导GSK3β无关的β-连环蛋白降解。我们的结果表明，TSC1控制BMSCs对骨细胞和脂肪细胞分化之间的平衡。还2018年美国骨骼和矿物学研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号