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首页> 外文期刊>Journal of Biomolecular Structure and Dynamics >Evaluation of (?6-p-cymene) ruthenium diclofenac complex as anticancer chemotherapeutic agent: interaction with biomolecules, cytotoxicity assays
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Evaluation of (?6-p-cymene) ruthenium diclofenac complex as anticancer chemotherapeutic agent: interaction with biomolecules, cytotoxicity assays

机译：评价（α6-yymene）钌双氯芬酸络合物作为抗癌化学治疗剂：与生物分子的相互作用，细胞毒性测定

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The designing of metal-based anticancer therapeutic agents can be optimized in a better and rapid way if the ligands utilized have standalone properties. Therefore, even when the organometallic/coordination complex (i.e., metallodrug) gets dissociated in extreme conditions, the ligand can endorse its biological properties. Herein, we have synthesized and characterized ?6-p-cymene ruthenium diclofenac complex. Furthermore, the ruthenium complex interactions with human serum albumin (HSA) and ct-DNA have been studied using various spectroscopic studies viz., UV, fluorescence, and circular dichroism and exhibited a significant binding propensity. Furthermore, in vitro cytotoxicity assays were carried out against human breast cancer “MCF-7” cell line. The ?6-p-cymene ruthenium diclofenac complex registered significant cytotoxicity with an IC50 value of ～25.0 μM which is comparable to the standard drugs. The ?6-p-cymene ruthenium diclofenac complex was able to decrease the MCF-7 cell proliferation and induced significant levels of apoptosis with relatively low toxicity.
机译：如果使用的配体具有独立性质，可以以更好快速的方式优化基于金属的抗癌治疗剂的设计。因此，即使当有机金属/配位复合物（即，Metallodrug）在极端条件下解离时，配体也能够赞同其生物学性质。在此，我们已经合成并表征了α6-p-cymene钌双氯氟芬酸络合物。此外，使用各种光谱研究VIZ研究了与人血清白蛋白（HSA）和CT-DNA的钌配合物相互作用，紫外，荧光和圆形二色性，并表现出显着的结合倾向。此外，对体外细胞毒性测定进行针对人乳腺癌“MCF-7”细胞系进行。 α6-p-cymene钌双氯芬酸甲酸二甲酸甲酰基复合物注册了显着的细胞毒性，IC 50值为〜25.0μm，其与标准药物相当。 α6-p-cyhene钌双氯氟乙烯络合物能够降低MCF-7细胞增殖，并诱导具有相对低毒性的显着水平的细胞凋亡。

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