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首页> 外文期刊>AIDS >Hepatitis C viral load, genotype 3 and interleukin-28B CC genotype predict mortality in HIV and hepatitis C-coinfected individuals
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Hepatitis C viral load, genotype 3 and interleukin-28B CC genotype predict mortality in HIV and hepatitis C-coinfected individuals

机译：丙型肝炎病毒载量，基因型3和白介素28B CC基因型可预测HIV和丙型肝炎合并感染个体的死亡率

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Objective: We hypothesized that hepatitis C virus (HCV) load and genotype may influence all-cause mortality in HIV-HCV-coinfected individuals. DESIGN AND Methods: Observational prospective cohort study. Mortality rates were compared in a time-updated multivariate Poisson regression analysis. Results: We included 264 consecutive HIV-HCV-coinfected individuals. During 1143 person years at risk (PYR) 118 individuals died [overall mortality rate 10 (95% confidence interval; 8, 12)/100 PYR]. In multivariate analysis, a 1 log increase in HCV viral load was associated with a 30% higher mortality risk [adjusted mortality rate ratio (aMRR): 1.30 (1.10,1.54)] when adjusted for sex, age, HIV exposure group, CD4 + cell count, HIV RNA, HCV genotype and interleukin (IL)-28B genotype. Further, HCV genotype 3 vs. 1 [aMRR: 1.83 (1.12, 2.98)] and HIV RNA [aMRR: 3.14 (1.37,7.17) for undetectable vs. just detectable HIV RNA] were independent predictors of mortality, whereas a higher CD4 + cell count was associated with a 41% reduction in mortality rate per 50 cell increase between 0 and 200cells/μl [aMRR: 0.59 (0.48, 0.72)] and a 10% reduction for increases above 200cells/μl [aMRR: 0.90 (0.82-0.98)]. IL28B) CC genotype was associated with 54% higher mortality risk [aMRR: 1.54 (0.89, 3.82] compared to TT genotype. Conclusion: High-HCV viral load, HCV genotype 3 and IL28B genotype CC had a significant influence on the risk of all-cause mortality among individuals coinfected with HIV-1. This may have consequences for the management of HIV-HCV-coinfected individuals.
机译：目的：我们假设丙型肝炎病毒（HCV）的载量和基因型可能影响HIV-HCV合并感染个体的全因死亡率。设计与方法：观察性前瞻性队列研究。在更新的多元Poisson回归分析中比较了死亡率。结果：我们纳入了264名连续感染HIV-HCV的个体。在1143人高危年份（PYR），有118人死亡[整体死亡率10（95％置信区间; 8、12）/ 100 PYR]。在多变量分析中，按性别，年龄，HIV暴露组，CD4 +进行校正后，HCV病毒载量每增加1 log就会增加30％的死亡风险[校正后的死亡率（aMRR）：1.30（1.10,1.54）]。细胞计数，HIV RNA，HCV基因型和白介素（IL）-28B基因型。此外，HCV基因型3对1 [aMRR：1.83（1.12，2.98）]和HIV RNA [aMRR：3.14（1.37,7.17）对于无法检测到只是可检测到的HIV RNA]是死亡率的独立预测因子，而较高的CD4 +细胞计数与0和200细胞/μl之间每增加50个细胞死亡率降低41％[aMRR：0.59（0.48，0.72）]和200细胞/μl以上增加10％死亡率降低[aMRR：0.90（0.82- 0.98）]。 IL28B）CC基因型与TT基因型相比死亡率高54％[aMRR：1.54（0.89，3.82]）结论：高HCV病毒载量，HCV基因型3和IL28B基因型CC对所有患病风险均具有显着影响-导致合并感染HIV-1的个体中的死亡率，这可能对HIV-HCV合并感染者的管理产生影响。

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