Protease inhibitor monotherapy is not associated with increased viral replication in lymph nodes

VinuesaD.; Parra-RuizJ.; ChuecaN.; AlvarezM.; Mu?oz-MedinaL.; GarciaF.; Hernandez-QueroJ.

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Protease inhibitor monotherapy is not associated with increased viral replication in lymph nodes

机译：蛋白酶抑制剂单一疗法与淋巴结中病毒复制增加无关

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There are concerns about residual viremia in sanctuary sites among patients on protease inhibitor monotherapy, so we aimed to study viro-immunological parameters in tonsilê1/4s lymphoid tissue of patients on highly active antiretroviral therapy (HAART) and on protease inhibitor monotherapy. Despite fully suppressed serum HIV viral load, we found viral replication in both groups; in addition, more patients had detectable proviral DNA among those on HAART, compared to those on protease inhibitor monotherapy (P=0.08), supporting the absence of a deleterious effect of protease inhibitor monotherapy.

机译：对于使用蛋白酶抑制剂单一疗法的患者中，圣所中残留的病毒血症存在担忧，因此我们旨在研究采用高活性抗逆转录病毒疗法（HAART）和蛋白酶抑制剂单一疗法的患者扁桃体1 / 4s淋巴组织的病毒免疫学参数。尽管完全抑制了血清HIV病毒载量，但两组均发现病毒复制。此外，与使用蛋白酶抑制剂单一疗法的患者相比，使用HAART的患者中可检出前病毒DNA的患者更多（P = 0.08），这表明缺乏蛋白酶抑制剂单一疗法的有害作用。

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《AIDS》 |2014年第12期|共3页
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VinuesaD.; Parra-RuizJ.; ChuecaN.; AlvarezM.; Mu?oz-MedinaL.; GarciaF.; Hernandez-QueroJ.;
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正文语种 eng
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1. Protease inhibitor monotherapy is not associated with increased viral replication in lymph nodes [J] . VinuesaD., Parra-RuizJ., ChuecaN., AIDS . 2014,第12期

机译：蛋白酶抑制剂单一疗法与淋巴结中病毒复制增加无关
2. Central nervous system HIV replication and HIV-related pachymeningitis in a patient on protease inhibitor monotherapy despite an undetectable plasma viral load [J] . PasquetA., AjanaF., MelliezH., AIDS . 2012,第13期

机译：尽管无法检测到血浆病毒载量，但接受蛋白酶抑制剂单药治疗的患者的中枢神经系统HIV复制和HIV相关性全脑膜炎
3. An increase in viral replicative capacity drives the evolution of protease inhibitor-resistant human immunodeficiency virus type 1 in the absence of drugs. [J] . van Maarseveen NM, de Jong D, Boucher CA, JAIDS: Journal of acquired immune deficiency syndromes . 2006,第2期

机译：在没有药物的情况下，病毒复制能力的提高驱动了蛋白酶抑制剂抗性人类免疫缺陷病毒1型的进化。
4. Inhibiting viral proteases:challenges and opportunities of induced fit [C] . Elisabetta Bianchi, Paolo Ingallinella, Daniela Fattori, European Peptide Symposium . 2002

机译：抑制病毒蛋白酶：诱导拟合的挑战和机遇
5. Insights into the Transcriptional Identities of Lymph Node Stromal Cell Subsets Isolated from Resting and Inflamed Lymph Nodes. [D] . Malhotra, Deepali. 2013

机译：深入了解从静止和发炎的淋巴结中分离出来的淋巴结基质细胞亚群的转录身份。
6. Combination of a Hepatitis C Virus NS3-NS4A Protease Inhibitor and Alpha Interferon Synergistically Inhibits Viral RNA Replication and Facilitates Viral RNA Clearance in Replicon Cells [O] . Kai Lin, Ann D. Kwong, Chao Lin 2004

机译：丙型肝炎病毒NS3-NS4A蛋白酶抑制剂和α干扰素的组合协同抑制病毒RNA复制并促进复制细胞中的病毒RNA清除。
7. Combination of a Hepatitis C Virus NS3-NS4A Protease Inhibitor and Alpha Interferon Synergistically Inhibits Viral RNA Replication and Facilitates Viral RNA Clearance in Replicon Cells [O] . Lin, Kai, Kwong, Ann D., Lin, Chao 2004

机译：丙型肝炎病毒NS3-NS4A蛋白酶抑制剂和α干扰素的组合协同抑制病毒RNA复制并促进复制细胞中的病毒RNA清除。

Protease inhibitor monotherapy is not associated with increased viral replication in lymph nodes

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