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首页> 外文期刊>Journal of cardiovascular electrophysiology >Assessment of ventricular electrophysiological characteristics at periinfarct zone of postmyocardial infarction in rabbits following stellate ganglion block.
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Assessment of ventricular electrophysiological characteristics at periinfarct zone of postmyocardial infarction in rabbits following stellate ganglion block.

机译:兔兔梗死后心肌梗死区心室电生理特性的评估。

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摘要

Assessment of Ventricular Electrophysiological Characteristics.The aim of this study was to investigate the characteristics of ventricular electrophysiology following stellate ganglion block (SGB) at periinfarct zone in rabbits with myocardial infarction (MI).Sixty-four rabbits were randomly assigned to 2 groups: MI (n = 32), ligation of the anterior descending coronary and sham operation (SO) (n = 32), without coronary ligation. Both MI and SO groups were divided into 4 subgroups according to right or left SGB and corresponding control (n = 8, each). After 8 weeks, 90% of monophasic action potential duration (MAPD90) of epicardium, midmyocardium and endocardium, transmural dispersion of repolarization (TDR), effective refractory period (ERP), and ventricular fibrillation threshold (VFT) were measured at the infarct border zone (MI group) and corresponding zone (SO group) following SGB. For SGB, 0.5 mL of 0.25% bupivacaine was used. Compared with the corresponding control group, in both the MI and SO groups, left SGB (LSGB) prolonged the MAPD90 of the 3 layers, reduced TDR, and increased ERP and VFT (P < 0.05). However, right SGB (RSGB) shortened MAPD90, increased TDR, and reduced ERP and VFT (P < 0.05).The results of this study demonstrate that LSGB can increase the electrophysiological stability of ventricular myocardium.
机译:对心室电生理学特征的评估。本研究的目的是探讨具有心肌梗死(MI)兔Periinfarct区的星形心脏区(SGB)后心室电生理学的特性(n = 32),联系前下降冠状动脉和假手术(SO)(SO)(n = 32),没有冠状动脉结扎。根据右或左单个SGB和相应的控制(每个),MI和SO组两组分为4个子组。在梗死边界区测量了8周后的80%的表皮,中性动作潜在持续时间(MAPD90)的外膜,中性和内膜,透气性耐火期(ERP)和心室原纤化阈值(VFT)的透气分散体(MI组)和SGB之后的相应区域(SO组)。对于SGB,使用0.5mL 0.25%的Bupivacaine。与相应的对照组相比,在MI等组中,左SGB(LSGB)延长了3层的MAPD90,减少了TDR和越来越多的ERP和VFT(P <0.05)。然而,右SGB(RSGB)缩短MAPD90,增加TDR和降低的ERP和VFT(P <0.05)。该研究的结果表明LSGB可以增加心室心肌的电生理稳定性。

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