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首页> 外文期刊>Journal of cardiovascular electrophysiology >Assessment of ventricular electrophysiological characteristics at periinfarct zone of postmyocardial infarction in rabbits following stellate ganglion block.
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Assessment of ventricular electrophysiological characteristics at periinfarct zone of postmyocardial infarction in rabbits following stellate ganglion block.

机译:星状神经节阻滞后兔心肌梗死后梗死区心室电生理特性的评估。

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Assessment of Ventricular Electrophysiological Characteristics.The aim of this study was to investigate the characteristics of ventricular electrophysiology following stellate ganglion block (SGB) at periinfarct zone in rabbits with myocardial infarction (MI).Sixty-four rabbits were randomly assigned to 2 groups: MI (n = 32), ligation of the anterior descending coronary and sham operation (SO) (n = 32), without coronary ligation. Both MI and SO groups were divided into 4 subgroups according to right or left SGB and corresponding control (n = 8, each). After 8 weeks, 90% of monophasic action potential duration (MAPD90) of epicardium, midmyocardium and endocardium, transmural dispersion of repolarization (TDR), effective refractory period (ERP), and ventricular fibrillation threshold (VFT) were measured at the infarct border zone (MI group) and corresponding zone (SO group) following SGB. For SGB, 0.5 mL of 0.25% bupivacaine was used. Compared with the corresponding control group, in both the MI and SO groups, left SGB (LSGB) prolonged the MAPD90 of the 3 layers, reduced TDR, and increased ERP and VFT (P < 0.05). However, right SGB (RSGB) shortened MAPD90, increased TDR, and reduced ERP and VFT (P < 0.05).The results of this study demonstrate that LSGB can increase the electrophysiological stability of ventricular myocardium.
机译:心室电生理特性的评估本研究的目的是研究心肌梗死(MI)家兔梗死区星状神经节阻滞(SGB)后的心室电生理特性.64只兔随机分为2组:MI (n = 32),结扎前降支和假手术(SO)(n = 32),无冠状动脉结扎。根据左或右SGB和相应的对照组(n = 8),将MI和SO组分为4个亚组。 8周后,在梗死边界区测量了90%的心外膜,心肌中层和心内膜的单相动作电位持续时间(MAPD90),跨壁复极极化(TDR),有效不应期(ERP)和心室纤颤阈值(VFT) (MI组)和SGB之后的相应区域(SO组)。对于SGB,使用0.5 mL的0.25%布比卡因。与相应的对照组相比,在MI组和SO组中,左SGB(LSGB)延长了三层的MAPD90,降低了TDR,并增加了ERP和VFT(P <0.05)。然而,正确的SGB(RSGB)缩短了MAPD90,增加了TDR,并降低了ERP和VFT(P <0.05)。本研究结果表明LSGB可以提高心室心肌的电生理稳定性。

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