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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness.
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Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness.

机译：定量人类脑中神经感受器：IV。 衰老和升高的D2样受体在精神分裂症和双相疾病中的影响。

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In a previous study of 10 drug-naive schizophrenic patients, the density of D2 dopamine receptors was found to be elevated in the caudate nucleus. The study raised questions about the influence of the age of the patients, the relationship of receptor density to psychosis, and the accuracy of the method used to obtain this evidence. Using positron emission tomography and constrained analysis of the brain uptake of the radioligand N-[11C]methyl-spiperone ([11C]NMSP), we tested four questions: Were the assumptions underlying the quantitation valid? Is there an age decline of the density of D2-like dopamine receptors in drug-naive schizophrenia and bipolar illness? If so, is it different from that observed in normal aging? Are D2-like dopamine receptors elevated at any age in either drug-naive schizophrenic or psychotic bipolar illness patients? NMSP and haloperidol partition volumes and plasma protein fractions were not significantly different among patient groups and normal volunteers. The model-derived assay of radioligand metabolites in plasma was confirmed by high-performance liquid chromatography in the patient groups. D2-like dopamine receptors declined with age, and the slope did not differ significantly between the schizophrenic patients, bipolar affective illness patients, and normal controls. Taking the effect of age into account, increases in D2 dopamine receptor density were found in seven psychotic patients with bipolar affective illness compared with seven nonpsychotic patients and 24 control subjects as well as in 22 drug-naive schizophrenic patients compared with the 24 control subjects.
机译：在先前的10例药物 - 幼稚精神分裂症患者的研究中，发现D2多巴胺受体的密度在尾状核中升高。该研究提出了关于患者年龄的影响的问题，受体密度与精神病的关系，以及用于获得此证据的方法的准确性。使用正电子发射断层扫描和约束分析了放射性末端的脑吸收的脑吸收，我们测试了四个问题：是定量依据的假设有效吗？在药物 - 幼稚精神分裂症和双相疾病中D2样多巴胺受体密度是否有年龄下降？如果是这样，它是否与正常老化中观察到的不同？ D2样多巴胺受体是否在任何年龄升高到药物 - 幼稚精神分裂症或精神病患者的任何年龄？ NMSP和氟哌啶醇分区体积和血浆蛋白质级分在患者组和正常志愿者之间没有显着差异。通过患者基团的高效液相色谱法证实了血浆中放射性原代代谢物的模型衍生测定。 D2样多巴胺受体随着年龄的增长而下降，精神分裂症患者，双相情感疾病患者和正常对照之间的斜坡没有显着差异。考虑到年龄的效果，与七个心脏情感患者的七名精神病患者和24例对照组织以及22例对照科治疗患者相比，在七个精神病患者中发现了D2多巴胺受体密度的增加，与24例对照受试者相比。

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