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首页> 外文期刊>Journal of chemical neuroanatomy >Neurons expressing estrogen receptor alpha differentially innervate the periaqueductal gray matter of female rats
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Neurons expressing estrogen receptor alpha differentially innervate the periaqueductal gray matter of female rats

机译：表达雌激素受体α的神经元差异地支配雌性大鼠的Periaquental灰质物质

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The periaqueductal gray matter (PAG) is a brainstem site involved in distinct autonomic and behavioral responses. Among them, the motor control of female sexual behavior, including lordosis, is well described. Lordosis reflex is highly dependent on increasing levels of estradiol that occur in the afternoon of the proestrus day in normally cycling females. This effect is thought to be mediated primarily via actions in the ventromedial nucleus of the hypothalamus (VMH). By binding to estrogen receptor alpha (ER alpha), estradiol changes the activity of VMH neurons that project to the PAG. Evidence also exists for the coordination of PAG outputs by estradiolresponsive neurons outside the VMH. However, a comprehensive analysis of these circuitries is not available. Using stereotaxic injection of the retrograde tracer Fluorogold in distinct columns of the PAG we performed a systematic mapping of neurons innervating the PAG and those coexpressing ER alpha immunoreactivity. We found that the forebrain projections to PAG columns are largely segregated and that most of the ER alpha expressing neurons preferentially target the lateral and the ventrolateral columns. Dual labeled neurons were mostly found in the intermediate subdivision of the lateral septal nucleus, the posterior aspect of the medial bed nucleus of the stria terminalis, the medial preoptic nucleus, the striohypothalamic nucleus and the ventrolateral VMH. Few dual labeled neurons were also observed in the arcuate nucleus, in the posterodorsal subdivision of the medial nucleus of the amygdala and in the ventral premammillary nucleus. Our findings indicate that ER alpha modulates sexual behavior in female rats via an integrated neural network that differentially innervate the columns of the PAG.
机译：PeriaqueDuctal灰质（PAG）是一个涉及不同的自主和行为反应的脑干网站。其中，良好描述的女性性行为的运动控制，包括卓越病。 Lordosis Reflex高度依赖于常循环雌性的前期雌二醇的雌二醇水平增加。认为这种效果主要通过下丘脑（VMH）的腹部细胞核中的动作介导。通过与雌激素受体α（ERα）结合，雌二醇会改变突出的VMH神经元的活性。证据还存在于VMH以外的雌二醇偏移神经元协调PAG输出。但是，对这些电路的全面分析不可用。在PAG的不同柱中使用立体胶片喷射器氟化物，我们进行了神经元的系统映射，该神经元接受了PAG和共同αα免疫反应性。我们发现对PAG柱的前脑突起大大偏析，并且表达神经元的大部分ERα优先靶向横向和腹侧柱。双标记的神经元大多是在侧面隔膜核的中间细胞中发现，中间床核的后岩核，内侧偏析核，血液酞菁核和腹侧VMH的后核。在弧形核中也观察到少量双标记的神经元，在杏仁核和腹侧细胞核中的后核的后细胞核中。我们的研究结果表明，ER alpha通过差异地支配PAG列的综合神经网络来调节女性大鼠的性行为。

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