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On the functional and structural characterization of hubs in protein-protein interaction networks

机译：蛋白质-蛋白质相互作用网络中枢纽的功能和结构表征

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摘要

A number of interesting issues have been addressed on biological networks about their global and local properties. The connection between the topological properties of proteins in Protein-Protein Interaction (PPI) networks and their biological relevance has been investigated focusing on hubs, i.e. proteins with a large number of interacting partners. We will survey the literature trying to answer the following questions: Do hub proteins have special biological properties Do they tend to be more essential than non-hub proteins Are they more evolutionarily conserved Do they play a central role in modular organization of the protein interaction network Are there structural properties that characterize hub proteins
机译：关于生物网络的全球和本地特性，已经解决了许多有趣的问题。已经研究了蛋白质-蛋白质相互作用（PPI）网络中蛋白质的拓扑特性与其生物学相关性之间的联系，重点是集线器，即具有大量相互作用伙伴的蛋白质。我们将调查文献以尝试回答以下问题：集线器蛋白是否具有特殊的生物学特性？它们是否比非集线器蛋白更重要？它们在进化上是否更保守？它们是否在蛋白相互作用网络的模块化组织中发挥核心作用？是否存在表征轮毂蛋白的结构特性

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